Journal article
Evaluating cognitive impairment in the early stages of Parkinson’s disease using the Cambridge brain sciences-cognitive platform
Clinical neurology and neurosurgery, Vol.232, pp.107866-107866
09/01/2023
DOI: 10.1016/j.clineuro.2023.107866
PMID: 37413872
Abstract
Non-motor symptoms (NMS) such as cognitive impairment are among common presentations in patients with Parkinson’s disease (PD). In parallel with motor symptoms, these impediments can affect PD patients’ quality of life. However, cognitive impairment has received less attention in early PD. On the other hand, the relationship between olfactory symptoms and cognitive impairment is unclear in early PD. Considering the importance of accurate and timely assessment of cognitive function in PD patients using readily available/validated tests, this study has employed the Cambridge Brain Sciences-Cognitive Platform (CBS-CP) as a computer-based tool to assess cognitive presentations in early PD patients.
Thirty-four eligible males and females were assigned to PD and healthy controls (HCs). The cognitive performance was assessed using CBS-CP and Mini-Mental State Examination (MMSE), and olfactory function was measured through the standardized olfactory Quick Smell test (QST).
PD patients had poorer performance in all CBS-CP tasks, including short-term memory, attention, and reasoning domains than HCs. Meanwhile, the verbal domain task scores showed no significant difference between groups. PD MMSE results were in the normal range (mean=26.96), although there was a significant difference between the PD and HCs groups (P = 0.000). Our results revealed no correlation between cognitive impairment and olfactory function in PD patients.
Given the widely studied features of CBS-CP and its reliability across published evidence, CBS-CP appears to be a suitable measurement to evaluate cognitive impairment in early PD with normal MMSE scores. It seems cognitive and olfactory impairments are independent in early PD.
The datasets generated during the current study are available from the corresponding author upon reasonable request.
•Cognitive impairment as a non-motor symptom is common in PD and affects patients’ quality of life.•Accurate and timely assessment of cognitive function in PD patients using readily available/validated tests is important.•The relationship between cognitive impairment and olfactory dysfunction as an important prodromal symptom in PD is controversial.•Using CBS-CP may be a suitable measurement to evaluate cognitive profile in PD patients.
Details
- Title: Subtitle
- Evaluating cognitive impairment in the early stages of Parkinson’s disease using the Cambridge brain sciences-cognitive platform
- Creators
- Maryam Hosseini - Shiraz University of Medical SciencesAfshin Borhani-Haghighi - Shiraz University of Medical SciencesPeyman Petramfar - Shiraz University of Medical SciencesAmin Abolhasani Foroughi - Shiraz University of Medical SciencesVahid Reza Ostovan - Shiraz University of Medical SciencesMohammad Nami - Canadian University of Dubai
- Resource Type
- Journal article
- Publication Details
- Clinical neurology and neurosurgery, Vol.232, pp.107866-107866
- DOI
- 10.1016/j.clineuro.2023.107866
- PMID
- 37413872
- NLM abbreviation
- Clin Neurol Neurosurg
- ISSN
- 0303-8467
- eISSN
- 1872-6968
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 09/01/2023
- Academic Unit
- Neurology
- Record Identifier
- 9985013729302771
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