Journal article
Evaluating depression and suicidality in tetrabenazine users with Huntington disease
Neurology, Vol.91(3), pp.e202-E207
07/17/2018
DOI: 10.1212/WNL.0000000000005817
PMID: 29925548
Abstract
To determine whether tetrabenazine (TBZ) use is associated with an increased incidence of depression and/or suicidal ideation.
In this retrospective cross-sectional study of the Enroll-HD database, we used multiple logistic regression analyses to determine whether TBZ use is associated with an increased incidence of depression and/or suicidal ideation. For both dependent variables (depression and suicidality), separate analyses were conducted on (1) all participants, (2) only participants with a history of depression, and (3) only participants with no history of depression. Adjustments were made for CAG repeat length, total motor score, total functional capacity, Symbol Digit Modalities Test score, sex, disease duration, history of depression (when applicable), antipsychotic use, and antidepressant use.
Compared to participants who were not using TBZ (n = 3,548), TBZ users (n = 543) did not have an increased risk of depression (odds ratio [OR] = 0.78,
= 0.064). Participants taking TBZ actually had a relatively lower risk of suicidality (OR = 0.61,
= 0.043). Among only participants with a history of depression, those using TBZ had a lower incidence of depression (OR = 0.71,
= 0.016) and suicidal ideation (OR = 0.57,
= 0.028) compared to those not using TBZ. Finally, among only participants with no history of depression, TBZ use was not associated with a higher incidence of depression (OR = 1.59,
= 0.18) or suicidality (OR = 1.43,
= 0.66) compared to those who were not using TBZ.
TBZ use was not associated with an increased incidence of depression or suicidality. These findings suggest that TBZ may be safe to use in patients with Huntington disease who have a history of depression.
Details
- Title: Subtitle
- Evaluating depression and suicidality in tetrabenazine users with Huntington disease
- Creators
- Jordan L Schultz - From the Departments of Pharmaceutical Care (J.L.S.), Neurology (J.L.S., A.K., P.C.N., J.A.K.), and Psychiatry (P.C.N., D.J.M., J.A.K.), and Stead Family Department of Pediatrics (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; Veterans Affairs Medical Center (A.K.), Iowa City; and University of Iowa College of Pharmacy (C.C.C.), Iowa City. Jordan-schultz@uiowa.eduAnnie Killoran - From the Departments of Pharmaceutical Care (J.L.S.), Neurology (J.L.S., A.K., P.C.N., J.A.K.), and Psychiatry (P.C.N., D.J.M., J.A.K.), and Stead Family Department of Pediatrics (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; Veterans Affairs Medical Center (A.K.), Iowa City; and University of Iowa College of Pharmacy (C.C.C.), Iowa CityPeg C Nopoulos - From the Departments of Pharmaceutical Care (J.L.S.), Neurology (J.L.S., A.K., P.C.N., J.A.K.), and Psychiatry (P.C.N., D.J.M., J.A.K.), and Stead Family Department of Pediatrics (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; Veterans Affairs Medical Center (A.K.), Iowa City; and University of Iowa College of Pharmacy (C.C.C.), Iowa CityChloe C Chabal - From the Departments of Pharmaceutical Care (J.L.S.), Neurology (J.L.S., A.K., P.C.N., J.A.K.), and Psychiatry (P.C.N., D.J.M., J.A.K.), and Stead Family Department of Pediatrics (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; Veterans Affairs Medical Center (A.K.), Iowa City; and University of Iowa College of Pharmacy (C.C.C.), Iowa CityDavid J Moser - From the Departments of Pharmaceutical Care (J.L.S.), Neurology (J.L.S., A.K., P.C.N., J.A.K.), and Psychiatry (P.C.N., D.J.M., J.A.K.), and Stead Family Department of Pediatrics (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; Veterans Affairs Medical Center (A.K.), Iowa City; and University of Iowa College of Pharmacy (C.C.C.), Iowa CityJohn A Kamholz - From the Departments of Pharmaceutical Care (J.L.S.), Neurology (J.L.S., A.K., P.C.N., J.A.K.), and Psychiatry (P.C.N., D.J.M., J.A.K.), and Stead Family Department of Pediatrics (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; Veterans Affairs Medical Center (A.K.), Iowa City; and University of Iowa College of Pharmacy (C.C.C.), Iowa City
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.91(3), pp.e202-E207
- DOI
- 10.1212/WNL.0000000000005817
- PMID
- 29925548
- NLM abbreviation
- Neurology
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Publisher
- United States
- Language
- English
- Date published
- 07/17/2018
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Pharmacy Practice and Science; Medicine Administration
- Record Identifier
- 9984003948402771
Metrics
29 Record Views