Journal article
Evaluating the Role of Staphylococcus aureus Nasal PCR in Pediatric Head and Neck Infections
The journal of pediatric pharmacology and therapeutics, Vol.26(7), pp.734-739
11/01/2021
DOI: 10.5863/1551-6776-26.7.734
PMCID: PMC8475794
PMID: 34588938
Abstract
OBJECTIVE
Vancomycin is often empirically used in the management of head and neck infections (HNIs) in children. The objective of this study was to determine the utility of Staphylococcus aureus (SA) nasal PCR to facilitate de-escalation of vancomycin for pediatric HNIs.
METHODS
This was a single-center, retrospective cohort study of pediatric patients who received empiric intravenous vancomycin for a diagnosis of HNIs between January 2010 and December 2019. Subjects were excluded if they met any of the following: confirmed/suspected coinfection of another site, dialysis, immunocompromised status, admission to the NICU, alternative diagnosis that did not require antibiotics, or readmission for HNIs within 30 days of previous admission. The primary outcome was time to de-escalation of vancomycin. Total duration of antibiotics, treatment failure, hospital length of stay (LOS), and incidence of acute kidney injury (AKI) were also assessed.
RESULTS
Of the 575 patients identified, 124 patients received an SA nasal PCR. The median time to de-escalation was 39.5 hours in those patients compared with 53.7 hours in patients who did not have a SA nasal PCR (p = 0.002). No difference was noted in total duration of all methicillin-resistant Staphylococcus aureus antibiotics, hospital LOS, treatment failure, and AKI.
CONCLUSIONS
In a large cohort of pediatric patients with HNIs, those who underwent testing with an SA nasal PCR spent less time receiving intravenous vancomycin, although their LOS was not significantly reduced. Further investigation is needed to better define the role of SA nasal PCRs in determining antibiotic therapy for HNIs.
Details
- Title: Subtitle
- Evaluating the Role of Staphylococcus aureus Nasal PCR in Pediatric Head and Neck Infections
- Creators
- Chandni PatelGuru BhoojhawonLukasz WeinerDanelle WilsonDerek ZhornePatrick Kinn
- Resource Type
- Journal article
- Publication Details
- The journal of pediatric pharmacology and therapeutics, Vol.26(7), pp.734-739
- DOI
- 10.5863/1551-6776-26.7.734
- PMID
- 34588938
- PMCID
- PMC8475794
- ISSN
- 1551-6776
- eISSN
- 2331-348X
- Language
- English
- Date published
- 11/01/2021
- Academic Unit
- Stead Family Department of Pediatrics; Pharmacy Practice and Science; Infectious Disease (Pediatrics); Hospital Medicine
- Record Identifier
- 9984353837902771
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