Journal article
Evaluating the effect of age on endometrial responsiveness to hormone replacement therapy: A histologic ultrasonographic, and tissue receptor analysis
Journal of assisted reproduction and genetics, Vol.10(1), pp.47-52
01/1993
DOI: 10.1007/BF01204440
PMID: 8499679
Abstract
Objective: Our objective was to characterize the endometria of women of various ages placed on similar estrogen/progesterone replacement regimens prior to attempted donor embryo transfer using histologic, ultrasonographic, and steroid receptor markers in order to determine if advancing age has a detrimental effect on uterine responsiveness to pharmacologic sex steroid replacement therapy.
Study design: This was a prospective open clinical trial. Functionally agonadal women aged 25 to 60 years receiving hormone replacement therapy underwent transvaginal ultrasound examination of the uterus followed by a timed endometrial biopsy on artificial cycle day 21. Endometrial histology and estrogen and progesterone receptors were analyzed from biopsy material. Subjects were assigned to three groups according to age: Group I, aged 25 to 39 years (n = 48); Group II, aged 40 to 49 years (n = 61); and Group III, aged 50 to 60 years (n = 13). Endometrial preparation was accomplished in all patients using the same sequential regimen consisting of oral micronized estradiol and intramuscular progesterone.
Results: Similar histologic, ultrasonographic, and steroid receptor characteristics were noted in all groups of patients regardless of age. A normal appearing midluteal secretory endometrium was demonstrated histologically in 85% of biopsies. However, 15% of biopsies exhibited intraluminal papillary excrescences within the glands and/or increase in the normal gland-to-stroma ratio. Three patients, one from each group, did not initially respond to replacement therapy and required further treatment.
Conclusion: Functionally agonadal women exhibit normal or near-normal endometrial responses to sex steroid replacement therapy designed to imitate the natural cycle through the sixth decade of life.
Details
- Title: Subtitle
- Evaluating the effect of age on endometrial responsiveness to hormone replacement therapy: A histologic ultrasonographic, and tissue receptor analysis
- Creators
- Mark V SauerRachel A MilesLaila DahmoushRichard J PaulsonMichael PressDean Moyer
- Resource Type
- Journal article
- Publication Details
- Journal of assisted reproduction and genetics, Vol.10(1), pp.47-52
- DOI
- 10.1007/BF01204440
- PMID
- 8499679
- ISSN
- 1058-0468
- eISSN
- 1573-7330
- Language
- English
- Date published
- 01/1993
- Academic Unit
- Pathology; Urology
- Record Identifier
- 9984047703802771
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