Journal article
Evaluating tumors and tumorlike lesions of the nasal cavity, the paranasal sinuses, and the adjacent skull base with diffusion-weighted MRI
Journal of computer assisted tomography, Vol.30(3), pp.490-495
05/2006
DOI: 10.1097/00004728-200605000-00023
PMID: 16778627
Abstract
The purpose of this study was to analyze the relationship of apparent diffusion coefficients (ADCs) to the malignant degree and the histopathological features of the lesions in the nasal cavity, the paranasal sinuses, and the adjacent skull base.
We evaluated the differences of the ADCs between the malignancies (n=18) and the benign lesions (n=6). The correlations between lesion ADCs and lesion cellularity, stroma, and necrosis were calculated.
The ADCs of the malignancies were significantly lower than the benign lesions (P<0.0125). The ADCs were inversely correlated with tumor cellularity (P<0.01, r=-0.556).
ADCs provide quantitative information that has limited utility in the differential diagnosis between malignant and benign lesions. The correlation of the histopathology of a lesion with ADCs is quite complex and affected by numerous tumor components besides cellularity including keratin, collagen, myxoid stroma, and necrosis.
Details
- Title: Subtitle
- Evaluating tumors and tumorlike lesions of the nasal cavity, the paranasal sinuses, and the adjacent skull base with diffusion-weighted MRI
- Creators
- Matthew L White - Department of Radiology, University of Nebraska Medical Center, Omaha 68198, USA. matthewwhite@unmc.eduYan ZhangRobert A Robinson
- Resource Type
- Journal article
- Publication Details
- Journal of computer assisted tomography, Vol.30(3), pp.490-495
- Publisher
- United States
- DOI
- 10.1097/00004728-200605000-00023
- PMID
- 16778627
- ISSN
- 0363-8715
- eISSN
- 1532-3145
- Language
- English
- Date published
- 05/2006
- Academic Unit
- Oral Pathology, Radiology and Medicine; Epidemiology; Pathology
- Record Identifier
- 9984047650302771
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