Journal article
Evaluation for genetic disease in kidney transplant candidates: A practice resource
American journal of transplantation, Vol.25(2), pp.237-249
02/2025
DOI: 10.1016/j.ajt.2024.10.019
PMCID: PMC13266825
PMID: 39488252
Abstract
The increasing availability of clinically approved genetic tests for kidney disease has spurred the growth in the use of these tests in kidney transplant practice. Neither the testing options nor the patient population where this should be deployed has been defined and its value in kidney transplant evaluation has not been demonstrated. Transplant providers may not always be aware of the limitations of genetic testing and may need guidance on comprehending test results and providing counsel, as many centers do not have easy access to a renal genetic counselor or a clinical geneticist. In this practice resource, a working group of nephrologists, geneticists and a genetic counselor provide a pragmatic, tailored approach to genetic testing, advocating for its use only where the genetic diagnosis or its exclusion can impact the choices available for transplantation or post-transplant management or the work-up of living donor candidates at increased risk for heritable disease.
Details
- Title: Subtitle
- Evaluation for genetic disease in kidney transplant candidates: A practice resource
- Creators
- Elizabeth G Ames - University of MichiganPrince M Anand - University of South Carolina LancasterMir Reza Bekheirnia - Baylor College of MedicineMona D. Doshi - University of MichiganMireille El Ters - Mayo ClinicMargaret E Freese - University of IowaRasheed A Gbadegesin - Duke UniversityLisa M Guay-Woodford - Children's Hospital of PhiladelphiaAnuja Java - Washington University in St. Louis School of MedicineDaniel Ranch - The University of Texas at San Antonio Health Science CenterNancy M Rodig - Boston Children's HospitalXiangling Wang - Cleveland Clinic Lerner College of MedicineChristie P Thomas - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of transplantation, Vol.25(2), pp.237-249
- DOI
- 10.1016/j.ajt.2024.10.019
- PMID
- 39488252
- PMCID
- PMC13266825
- NLM abbreviation
- Am J Transplant
- ISSN
- 1600-6135
- eISSN
- 1600-6143
- Publisher
- Elsevier Inc; NEW YORK
- Grant note
- Scientific Review Committee for Dicerna Pharmaceuticals
Scientific Review Committee for Dicerna Pharmaceuticals. X.W. serves on the Scientific Advisory Board of Natera. C.P.T. is a site PI for Vertex Pharmaceuticals.
- Language
- English
- Electronic publication date
- 10/31/2024
- Date published
- 02/2025
- Academic Unit
- Stead Family Department of Pediatrics; Obstetrics and Gynecology; Nephrology; Internal Medicine
- Record Identifier
- 9984743398702771
Metrics
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