Journal article
Evaluation of 134Ce as a PET imaging surrogate for antibody drug conjugates incorporating 225Ac
Nuclear medicine and biology, Vol.110-111, pp.28-36
04/22/2022
DOI: 10.1016/j.nucmedbio.2022.04.007
PMID: 35512517
Abstract
The in vivo generator 134Ce/134La has the potential to serve as a PET imaging surrogate for both alpha-emitting 225Ac and 227Th radionuclides due to the unique CeIII/CeIV redox couple and the relatively long half-life of 134Ce. Furthermore, the purpose of this study was to demonstrate the compatibility of 134Ce with DOTA-based antibody drug conjugates, which would act as therapeutic agents when incorporating 225Ac.
Details
- Title: Subtitle
- Evaluation of 134Ce as a PET imaging surrogate for antibody drug conjugates incorporating 225Ac
- Creators
- Tyler A BaileyJennifer N Wacker - Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)] (ORCID:0000000154111986Dahlia D An - Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)] (ORCID:0000000287636735Korey P CarterRyan C Davis - Menlo SchoolVeronika Mocko - Los Alamos National Lab. (LANL), Los Alamos, NM (United States)] (ORCID:0000000160416778John Larrabee - Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)Katherine M Shield - Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)] (ORCID:0000000227342516Mila Nhu Lam - Los Alamos National Lab. (LANL), Los Alamos, NM (United States)] (ORCID:0000000151616604Corwin H Booth - Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)] (ORCID:0000000168270080Rebecca J Abergel
- Resource Type
- Journal article
- Publication Details
- Nuclear medicine and biology, Vol.110-111, pp.28-36
- DOI
- 10.1016/j.nucmedbio.2022.04.007
- PMID
- 35512517
- NLM abbreviation
- Nucl Med Biol
- ISSN
- 0969-8051
- eISSN
- 1872-9614
- Publisher
- Elsevier
- Language
- English
- Date published
- 04/22/2022
- Academic Unit
- Chemistry
- Record Identifier
- 9984279253302771
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