Journal article
Evaluation of Low-dose Buprenorphine Initiation With Buprenorphine Buccal Films in Hospitalized Patients: A Retrospective Cohort Study
Journal of addiction medicine, Vol.18(1), pp.42-47
01/01/2024
DOI: 10.1097/ADM.0000000000001236
PMID: 37847570
Abstract
Objective
Low-dose buprenorphine initiation (LDBI) strategies to transition patients from full opioid agonists to buprenorphine have previously been described using sublingual films, intravenous solution, transdermal patches, and, more recently, buccal films. The objective of this study was to describe the effectiveness of LDBI using novel titration schedules with buccal films.
Methods
This is a retrospective cohort study of hospitalized patients with opioid use disorder (OUD) or physiologic dependence to opioids who underwent LDBI with buprenorphine buccal films at NYU Langone Health. Two LDBI protocols were evaluated, including a short titration schedule over 4 days and a long schedule over 7 days. The primary outcomes of interest included LDBI completion rates and incidence of opioid withdrawal.
Results
Forty-two patients underwent 46 LDBIs at NYU Langone Health between October 2020 and April 2022. The cohort comprised patients with OUD (57%), chronic pain with OUD (33%), and chronic pain without OUD (10%). Indications for LDBI most commonly included co-occurring pain precluding discontinuation of full opioid agonists (72%), prior history of precipitated withdrawal (30%), and methadone use (23%). The overall completion rate of LDBI was 78%. Withdrawal was encountered in 33% of patients; however, only 2 patients required LDBI discontinuation as a result. On multivariate analysis, a diagnosis of OUD was independently associated with withdrawal during LDBI.
Conclusions
Buprenorphine buccal films can successfully be used off-label to facilitate LDBI in the hospital setting. We present 4- and 7-day titration protocols, which were well-tolerated, and provide practical considerations for use.
Details
- Title: Subtitle
- Evaluation of Low-dose Buprenorphine Initiation With Buprenorphine Buccal Films in Hospitalized Patients: A Retrospective Cohort Study
- Creators
- Serena Arnouk - University of IowaJeffrey R. Wunderlich - University of IowaS. Alex Sidelnik - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Journal of addiction medicine, Vol.18(1), pp.42-47
- DOI
- 10.1097/ADM.0000000000001236
- PMID
- 37847570
- NLM abbreviation
- J Addict Med
- ISSN
- 1932-0620
- eISSN
- 1935-3227
- Number of pages
- 6
- Language
- English
- Date published
- 01/01/2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985240896402771
Metrics
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