Evaluation of Older Persons with Mild Cognitive Deficits: Potential Utility of Magnetic Resonance Imaging

SUSAN K SCHULTZ; VINCENT MAGNOTTA; KEVIN DUFF; LAURIE L BOLES PONTO; DAVID J MOSER

doi:10.1080/10401230802437530

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Evaluation of Older Persons with Mild Cognitive Deficits: Potential Utility of Magnetic Resonance Imaging

Journal article

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Evaluation of Older Persons with Mild Cognitive Deficits: Potential Utility of Magnetic Resonance Imaging

SUSAN K SCHULTZ, VINCENT MAGNOTTA, KEVIN DUFF, LAURIE L BOLES PONTO and DAVID J MOSER

Annals of clinical psychiatry, Vol.20(4), pp.204-208

2008

DOI: 10.1080/10401230802437530

PMCID: PMC3392192

PMID: 19034752

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Abstract

Background. This study evaluated brain volumes in healthy older subjects without dementia who presented with memory complaints. The objective was to examine cortical volumes in relation to cognitive performance among patients who do not have dementia, but who do have mild cognitive deficits. Methods. Fifteen participants were evaluated (mean age = 71.8 ± 6.2). Brain structure was measured via high-resolution magnetic resonance imaging to quantify gray and white matter volumes. Volumetric measures were assessed relative to cognitive function in separate regression models controlling for total cerebral volume. Reported here are measures of global cognitive performance using the Mattis Dementia Rating Scale (DRS) in relation to volumetric measures. Results. Baseline MMSE scores ranged from 27 to 30 (mean = 29.3; SD = 0.9). After controlling for total cerebral volume, we observed that lower white matter volume in the temporal lobe [F(1,14) = 5.72, p = 0.03] was associated with lower performance on the Mattis Dementia Rating Scale (DRS). Conclusions. Structural imaging may help provide useful clinical information in the context of mild cognitive decline. Currently, the diagnosis of dementia relies on longitudinal measures of cognition. Future studies will help determine whether the addition of brain imaging may enhance diagnostic certainty as well as predict long-term outcome.

Aging

Cognition

Imaging

Memory

Details

Title: Subtitle: Evaluation of Older Persons with Mild Cognitive Deficits: Potential Utility of Magnetic Resonance Imaging
Creators: SUSAN K SCHULTZ - University of Iowa Department of Psychiatry, Carver College of Medicine, Iowa City, IA, USA
VINCENT MAGNOTTA - University of Iowa Department of Radiology, Carver College of Medicine, Iowa City, IA, USA
KEVIN DUFF - University of Iowa Department of Psychiatry, Carver College of Medicine, Iowa City, IA, USA
LAURIE L BOLES PONTO - University of Iowa Department of Radiology, Carver College of Medicine, Iowa City, IA, USA
DAVID J MOSER - University of Iowa Department of Psychiatry, Carver College of Medicine, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Annals of clinical psychiatry, Vol.20(4), pp.204-208
DOI: 10.1080/10401230802437530
PMID: 19034752
PMCID: PMC3392192
NLM abbreviation: Ann Clin Psychiatry
ISSN: 1040-1237
eISSN: 1547-3325
Grant note: R01 CA122934 || CA / National Cancer Institute : NCI
Language: English
Date published: 2008
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Medicine Administration; Internal Medicine
Record Identifier: 9984003489602771

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