Journal article
Evaluation of Placental and Fetal Tissue Specimens for Zika Virus Infection — 50 States and District of Columbia, January–December, 2016
MMWR. Morbidity and mortality weekly report, Vol.66(24), pp.636-643
06/23/2017
DOI: 10.15585/mmwr.mm6624a3
PMCID: PMC5657799
PMID: 28640798
Abstract
Summary
What is already known about this topic?
Zika virus infection during pregnancy can cause microcephaly and other brain abnormalities. Diagnosis of Zika virus infection is challenging because of serologic cross-reactivity with other related flaviviruses and limited duration of viremia. Zika virus RNA can be detected in placental and fetal tissues, which can provide an opportunity to diagnose maternal Zika virus infection and can be considered when maternal serologic testing is not definitive or is negative outside the optimal testing window.
What is added by this report?
In the 50 U.S. states and District of Columbia, placental testing provided a confirmed diagnosis of recent maternal Zika virus infection for 10% of live births with possible maternal exposure to Zika virus that lacked definitive evidence of a maternal or congenital Zika virus infection. This included pregnancies with clinical laboratory evidence of recent unspecified maternal flavivirus infection, and those with negative maternal Zika virus IgM, where possible maternal exposure occurred >12 weeks before serum collection.
What are the implications for public health practice?
Testing of placental tissues from live births provided definitive evidence of maternal Zika virus infection. Although the proportion of live births for which placental tissue was RT-PCR–positive for Zika virus was relatively low, testing of placental tissues from live births can continue to be considered when results of maternal Zika virus testing are not definitive or testing is not performed within the optimal time. Ensuring appropriate Zika virus testing and clinical follow-up of infants, according to published CDC guidance is critical in order to identify congenital Zika virus infection.
Details
- Title: Subtitle
- Evaluation of Placental and Fetal Tissue Specimens for Zika Virus Infection — 50 States and District of Columbia, January–December, 2016
- Creators
- Sarah Reagan-SteinerRegina SimeoneElizabeth SimonJulu BhatnagarTitilope OduyeboRebecca FreeAmy M. DenisonDemi B. RabeneckSascha EllingtonEmily PetersenJoy GaryGillian HaleM. Kelly KeatingRoosecelis B. MartinesAtis MuehlenbachsJana RitterEllen LeeAlexander DavidsonErin ConnersSarah ScotlandKayleigh SandhuAndrea BinghamElizabeth KassensLou SmithKirsten St. GeorgeNina AhmadMary TannerSuzanne BeaversBrooke MiersKelley VanMaldeghemSumaiya KhanIngrid RabeCarolyn GouldDana Meaney-DelmanMargaret A. HoneinWun-Ju ShiehDenise J. JamiesonMarc FischerSherif R. ZakiMelissa Kretschmer - Maricopa County Department of Public HealthKara Tarter - Arizona Department of Health ServicesHayley Yaglom - Arizona Department of Health ServicesShoruq Alhajmohammad - California Department of Public HealthDildeep Chhabra - California Department of Public HealthWendy Jilek - California Department of Public HealthMeghana Madala - California Department of Public HealthSharon Messenger - California Department of Public HealthCharsey Cole Porse - California Department of Public HealthMaria Salas - California Department of Public HealthDiana Singh - California Department of Public HealthSarah Skallet - California Department of Public HealthSimiloluwa Sowunmi - California Department of Public HealthNatalie S. Marzec - Colorado Department of Public Health and EnvironmentKarin Davis - Connecticut Department of Public HealthBrenda Esponda-Morrison - Connecticut Department of Public HealthM. Zachariah Fraser - Connecticut Department of Public HealthColleen Ann O'Connor - Connecticut Department of Public HealthWendy M. Chung - Dallas CountyFolasuyi Richardson - Dallas CountyMeredith E. Stocks - Dallas CountyAmanda Marie Bundek - Delaware Division of Public HealthJennifer L. Zambri - Delaware Division of Public HealthAshley Allen - Florida Department of Health, Bureau of Public Health Laboratories-MiamiMarie Ketty Etienne - Miami Dade CollegeJennifer Jackson - Florida Department of Health in Orange CountyVanessa Landis - Florida Department of HealthTeresa Logue - Miami Dade CollegeNicole Muse - Miami Dade CollegeJuliana Prieto - Florida Department of HealthMercedes Rojas - Miami Dade CollegeAmanda Feldpausch - Georgia Department of Public HealthTeri Graham - Georgia Department of Public HealthSylvia Mann - Hawaii Department of HealthSarah Y. Park - Hawaii Department of HealthDebbie Freeman - Illinois Department of Public HealthEmily J. Potts - Indiana State Department of HealthTaryn Stevens - Indiana State Department of HealthSean Simonson - Louisiana Department of HealthJulius L. Tonzel - Louisiana Department of HealthShari Davis - Maine Department of Health and Human ServicesSara Robinson - Maine Department of Health and Human ServicesJudie K. Hyun - Maryland Department of HealthErin Maureen Jenkins - Maryland Department of HealthCatherine Brown - Massachusetts Department of Public HealthSusan Soliva - Massachusetts Department of Public HealthElizabeth Schiffman - Minnesota Department of HealthPaul Byers - Mississippi State Department of HealthSheryl Hand - Mississippi State Department of HealthChristine L. Mulgrew - Montana Department of Health and Human ServicesJeff Hamik - Nebraska Department of Health and Human ServicesSamir Koirala - Nebraska Department of Health and Human ServicesElizabeth Ludwig - Nebraska Department of Health and Human ServicesCarolyn R. Fredette - New Hampshire Department of Health and Human ServicesAbigail A. Mathewson - New Hampshire Department of Health and Human ServicesKristin Garafalo - New Jersey Department of HealthKaren Worthington - New Jersey Department of HealthAbubakar Ropri - New Mexico Department of HealthDanielle Bloch - New York City Department of Health & Mental HygieneSandhya Clark - New York City Department of Health & Mental HygieneHannah Cooper - New York City Department of Health & Mental HygieneAnnie D. Fine - New York City Department of Health & Mental HygieneGili Hrusa - New York City Department of Health & Mental HygieneMartha Iwamoto - New York City Department of Health & Mental HygieneHannah Kubinson - New York City Department of Health & Mental HygieneChristopher T. Lee - New York City Department of Health & Mental HygieneSally Slavinski - New York City Department of Health & Mental HygieneEliza Wilson - New York City Department of Health & Mental HygieneAnn Winters - New York City Department of Health & Mental HygieneDavid Yi Yang - New York City Department of Health & Mental HygieneJulius N. Ade - New York State Department of HealthZahra Alaali - New York State Department of HealthKimberly Alvarez - New York State Department of HealthP. Bryon Backenson - New York State Department of HealthDebra Blog - New York State Department of HealthAmy Dean - Wadsworth CenterElizabeth Dufort - New York State Department of HealthAndrea Marias Furuya - Wadsworth CenterMeghan Fuschino - Wadsworth CenterRene Hull - Wadsworth CenterMatthew Kleabonas - Wadsworth CenterKaren Kulas - Wadsworth CenterPhilip Kurpiel - New York State Department of HealthLou Ann Lance - New York State Department of HealthEmaly Leak - Wadsworth CenterRonald J. Limberger - Wadsworth CenterStephanie Ostrowski - New York State Department of HealthMaryJo Polfleit - New York State Department of HealthAmy Robbins - New York State Department of Health Bureau of Communicable Disease ControlJemma V. Rowlands - New York State Department of HealthInderbir Sohi - New York State Department of Health, CDCJamie N. Sommer - New York State Department of Health Bureau of Communicable Disease ControlJennifer White - New York State Department of HealthDorothy Wiley - New York State Department of HealthLi Zeng - Wadsworth CenterRonna L. Chan - North Carolina Department of Health and Human Services Division of Public HealthJennifer MacFarquhar - North Carolina Department of Health and Human Services Division of Public HealthLaura Cronquist - North Dakota Department of HealthLeah Lind - Pennsylvania Department of HealthKumar Nalluswami - Pennsylvania Department of HealthDana Perella - Philadelphia Department of Public HealthDiane S. Brady - Rhode Island Department of HealthMichael Gosciminski - Rhode Island Department of HealthPatricia McAuley - Rhode Island Department of HealthBridget E. Teevan - Rhode Island Department of HealthDaniel Drociuk - South Carolina Department of Health and Environmental ControlVinita Leedom - South Carolina Department of Health and Environmental ControlBrian Witrick - South Carolina Department of Health and Environmental ControlJan Bollock - South Dakota Department of HealthLon Kightlinger - South Dakota Department of HealthMarie Bottomley Hartel - Tennessee Department of HealthLoraine Swanson Lucinski - Tennessee Department of HealthMorgan McDonald - Tennessee Department of HealthAngela M. Miller - Tennessee Department of HealthTori Armand Ponson - Tennessee Department of HealthLaura Price - Tennessee Department of HealthKelly Broussard - Texas Department of State Health ServicesAmy E. Nance - Utah Department of HealthDallin Peterson - Utah Department of HealthBrennan Martin - Vermont Department of HealthShea Browne - Virginia Department of HealthLaToya A. Griffin-Thomas - Virginia Division of Consolidated Laboratory ServicesJennifer O. Macdonald - Virginia Department of HealthJillian Neary - Washington State Department of HealthHanna Oltean - Washington State Department of HealthAlys Adamski - CDCMadelyn Baez-Santiago - CDCBrigid C. Bollweg - CDCJanet D. Cragan - CDCYokabed Ermias - CDCLindsey B. C. Estetter - CDCShannon Fleck-Derderian - CDC, ORISECynthia S. Goldsmith - CDCMatthew R. Groenewold - CDCHeather Hayes - CDCIrogue Igbinosa - CDCTiffany Gayle Jenkinson - CDCAbbey M. Jones - CDCAmanda Lewis - CDCCynthia A. Moore - CDCKimberly B. Newsome - CDCVaunita Parihar - CDCMitesh M. Patel - CDCAnna Paulino - CDCSonja A. Rasmussen - CDCMeghan Raycraft - CDCMegan R Reynolds - CDCDominique C. Rollin - CDCJeanine H. Sanders - CDCCarrie Shapiro-Mendoza - CDCLuciana Silva-Flannery - CDCPamela Spivey - CDCAlphonse K. Tshiwala - CDCTonya R. Williams - CDCWilliam A. Bower - CDCElizabeth Davlantes - Epidemic Intelligence ServiceTerra R. Forward - CDCRena Fukunaga - CDC, EISJonas Hines - CDCShaohua Sean Hu - CDCJessica Leung - CDCLillianne Lewis - CDCStacey Martin - CDCLucy McNamara - CDCJohn D. Omura - CDCCandice L. Robinson - CDCKristine Schmit - CDCJulie L. Self - CDC, EISMinesh Shah - CDCAnne Straily - CDC, EISElizabeth A. Van Dyne - CDCZika Virus Response Epidemiology and Surveillance Task Force Pathology TeamMilan Vu - CDCCharnetta Williams - CDC, EIS
- Resource Type
- Journal article
- Publication Details
- MMWR. Morbidity and mortality weekly report, Vol.66(24), pp.636-643
- Publisher
- Centers for Disease Control and Prevention
- DOI
- 10.15585/mmwr.mm6624a3
- PMID
- 28640798
- PMCID
- PMC5657799
- ISSN
- 0149-2195
- eISSN
- 1545-861X
- Language
- English
- Date published
- 06/23/2017
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446274002771
Metrics
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