Evaluation of Structure-Function Relationships in Asthma using Multidetector CT and Hyperpolarized He-3 MRI

Sean B Fain; Guillermo Gonzalez-Fernandez; Eric T Peterson; Michael D Evans; Ronald L Sorkness; Nizar N Jarjour; William W Busse; Janet E Kuhlman

doi:10.1016/j.acra.2007.10.019

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Evaluation of Structure-Function Relationships in Asthma using Multidetector CT and Hyperpolarized He-3 MRI

Journal article

Peer reviewed

Evaluation of Structure-Function Relationships in Asthma using Multidetector CT and Hyperpolarized He-3 MRI

Sean B Fain, Guillermo Gonzalez-Fernandez, Eric T Peterson, Michael D Evans, Ronald L Sorkness, Nizar N Jarjour, William W Busse and Janet E Kuhlman

Academic radiology, Vol.15(6), pp.753-762

2008

DOI: 10.1016/j.acra.2007.10.019

PMCID: PMC2744977

PMID: 18486011

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https://www.ncbi.nlm.nih.gov/pmc/articles/2744977View

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Abstract

Although multiple detector computed tomography (MDCT) and hyperpolarized gas magnetic resonance imaging (HP MRI) have demonstrated ability to detect structural and ventilation abnormalities in asthma, few studies have sought to exploit or cross-validate the regional information provided by these techniques. The purpose of this work is to assess regional disease in asthma by evaluating the association of sites of ventilation defect on HP MRI with other regional markers of airway disease, including air trapping on MDCT and inflammatory markers on bronchoscopy. Both HP MRI using helium-3 and MDCT were acquired in the same patients. Supervised segmentation of the lung lobes on MRI and MDCT facilitated regional comparisons of ventilation abnormalities in the lung parenchyma. The percentage of spatial overlap was evaluated between regions of ventilation defect on HP MRI and hyperlucency on MDCT to determine associations between obstruction and likely regions of gas trapping. Similarly, lung lobes with high defect volume were compared to lobes with low defect volume for differences in inflammatory cell number and percentage using bronchoscopic assessment. There was significant overlap between sites of ventilation defect on HP MRI and hyperlucency on MDCT suggesting that sites of airway obstruction and air trapping are associated in asthma. The percent ( r = 0.68; P = .0039) and absolute ( r = 0.61; P = .0125) number of neutrophils on bronchoalveolar lavage for the sampled lung lobe also directly correlated with increased defect volume. These results show promise for using image guidance to assess specific regions of ventilation defect or air trapping in heterogeneous obstructive lung diseases such as asthma.

Asthma

functional imaging

hyperpolarized gas

lungs

MDCT

MRI

Details

Title: Subtitle: Evaluation of Structure-Function Relationships in Asthma using Multidetector CT and Hyperpolarized He-3 MRI
Creators: Sean B Fain - University of Wisconsin–Madison
Guillermo Gonzalez-Fernandez - University of Wisconsin–Madison
Eric T Peterson - University of Wisconsin–Madison
Michael D Evans - University of Wisconsin–Madison
Ronald L Sorkness - University of Wisconsin–Madison
Nizar N Jarjour - University of Wisconsin–Madison
William W Busse - University of Wisconsin–Madison
Janet E Kuhlman - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Academic radiology, Vol.15(6), pp.753-762
DOI: 10.1016/j.acra.2007.10.019
PMID: 18486011
PMCID: PMC2744977
NLM abbreviation: Acad Radiol
ISSN: 1076-6332
eISSN: 1878-4046
Publisher: Elsevier Inc
Language: English
Date published: 2008
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
Record Identifier: 9984275059302771

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