Journal article
Evaluation of Variable Thin-Cap Fibroatheroma Definitions and Association of Virtual Histology-Intravascular Ultrasound Findings With Cavity Rupture Size
The American journal of cardiology, Vol.118(2), pp.162-169
07/15/2016
DOI: 10.1016/j.amjcard.2016.04.050
PMID: 27289292
Abstract
The accepted definition of virtual histology intravascular ultrasound (IVUS-VH) thin-cap fibroatheroma (TCFA) is only a modest predictor of plaque rupture (PR). We sought to determine the relation between IVUS-VH findings and culprit lesions with PR using computational analysis. A total of 80 culprit lesions from 80 patients with stable angina (n = 37), unstable angina (n = 20), and myocardial infarction (n = 23) were divided into those with (n = 15) and without PR (n = 65). By use of automated computational analysis, the standard IVUS-VH TCFA criterion and 124 additional criteria were compared. The standard TCFA definition demonstrated modest ability to discriminate lesions with and without PR (sensitivity 87%, specificity 37%, PPV 0.24, and NPV 0.92). Of 124 additional IVUS-VH TCFA definitions, only 2 improved the discriminative ability even modestly. However, a positive correlation was demonstrated between cavity size and necrotic core percentage (r = 0.78, p <0.01) and a negative correlation with percentage of fibrous tissue (r = −0.81, p <0.01). In conclusion, IVUS-VH criteria were only modestly associated with PR, without significant improvement by varying IVUS-VH TCFA features, but IVUS-VH features of ruptured plaques were strongly correlated with cavity size.
Details
- Title: Subtitle
- Evaluation of Variable Thin-Cap Fibroatheroma Definitions and Association of Virtual Histology-Intravascular Ultrasound Findings With Cavity Rupture Size
- Creators
- Taishi Hirai - Division of Cardiology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Loyola University Medical Center, Maywood, IllinoisZhi Chen - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IowaLing Zhang - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IowaShamsa Baaj - Division of Cardiology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Loyola University Medical Center, Maywood, IllinoisTomas Kovarnik - Department of Medicine, Charles University Hospital, Prague, Czech RepublicKatie Porcaro - Division of Cardiology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Loyola University Medical Center, Maywood, IllinoisJohn Kaminski - Division of Cardiology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Loyola University Medical Center, Maywood, IllinoisStephen Hawn - Division of Cardiology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Loyola University Medical Center, Maywood, IllinoisAnoop Agrawal - Division of Cardiology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Loyola University Medical Center, Maywood, IllinoisNader Makki - Division of Cardiology, Department of Medicine, Ohio State University, Columbus, OhioRichard Downe - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IowaAndreas Wahle - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IowaMilan Sonka - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IowaJohn J Lopez - Division of Cardiology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Loyola University Medical Center, Maywood, Illinois
- Resource Type
- Journal article
- Publication Details
- The American journal of cardiology, Vol.118(2), pp.162-169
- DOI
- 10.1016/j.amjcard.2016.04.050
- PMID
- 27289292
- NLM abbreviation
- Am J Cardiol
- ISSN
- 0002-9149
- eISSN
- 1879-1913
- Publisher
- Elsevier Inc
- Grant note
- R01 HL063373; R01 EB00464 / the National Institutes of Health, Bethesda, MD (http://dx.doi.org/10.13039/100000002) IGA 2012 NT/13224-4 / IGA
- Language
- English
- Date published
- 07/15/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984047620602771
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