Journal article
Evaluation of a Novel Silicate Substituted Hydroxyapatite Bone Graft Substitute in a Rabbit Posterolateral Fusion Model
The Iowa orthopaedic journal, Vol.33, pp.25-32
2013
PMCID: PMC3748888
PMID: 24027457
Appears in Diamond Open Access
Abstract
Study Design/Setting
Randomized, controlled study in a laboratory setting. Blinded observations/assessment of study outcomes.
Objective
The purpose of this study is to determine the performance characteristics of a novel silicate-substituted hydroxyapatite bone graft substitute (BGS), SiCaP EP (Baxter Healthcare/ ApaTech, Elstree, UK), in a stand-alone mode, a stand-alone with bone marrow aspirate (BMA) mode, and an extender mode with iliac crest autograft (ICBG) in a rabbit posterolateral spine fusion model. The investigational BGS is compared to a standard iliac crest autograft (ICBG) control.
Summary of Background Data
The rabbit posterolateral fusion model is an established environment for testing of fusion efficacy. It offers the opportunity to obtain radiographic, histological, and biomechanical data on novel bone graft substitutes.
Methods
One hundred and twenty rabbits were entered into the study with 116 used for analysis. Bilateral posterolateral lumbar intertransverse fusions were performed at L5-L6. The lateral two thirds of the transverse processes were decorti cated and covered with graft material in the following five groups: ICBG, SiCaP EP stand-alone, SiCaP EP with BMA (1:0.5 by volume), and SiCaP EP with ICBG (1:3 by volume). Rabbits were necropsied at 4, 8, and 12-week time points and fusion rate, quantity, and quality was evaluated based on manual palpation, mechanical stiffness testing, pqCT, and histological assessment.
Results
SiCaP EP, ICBG+SiCaP EP (3:1), and SiCaP EP+BMA (1:0.5) compare favorably to iliac crest autologous bone by multiple metrics in this rabbit posterolateral fusion model. Fusion efficacy via manual palpation and mechanical stiffness testing metrics indicate that all SiCaP EP groups had similar group-to-group performance, and were not significantly different than the ICBG control at each time period evaluated.
Conclusions
In this commonly used rabbit posterolateral fusion model, SiCaP EP utilized as a stand-alone, as a stand-alone with BMA, and as an autograft (ICBG) extender produces results that are clinically and radiographically similar to ICBG.
Details
- Title: Subtitle
- Evaluation of a Novel Silicate Substituted Hydroxyapatite Bone Graft Substitute in a Rabbit Posterolateral Fusion Model
- Creators
- Douglas C Fredericks - University of IowaEmily B Petersen - University of IowaNikhil Sahai - University of IowaKatherine Gibson N Corley - University of IowaNicole DeVries - .Nicole M Grosland - .Joseph D Smucker - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Iowa orthopaedic journal, Vol.33, pp.25-32
- PMID
- 24027457
- PMCID
- PMC3748888
- NLM abbreviation
- Iowa Orthop J
- ISSN
- 1541-5457
- eISSN
- 1555-1377
- Publisher
- Dept. of Orthopaedics, The University of Iowa; United States
- Language
- English
- Date published
- 2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Technology Institute; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984185462102771
Metrics
8 Record Views