Journal article
Evaluation of a chloride-based Zr-89 isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin
Nuclear medicine and biology, Vol.64-65, pp.1-7
09/01/2018
DOI: 10.1016/j.nucmedbio.2018.06.003
PMCID: PMC6153039
PMID: 30015090
Abstract
Introduction: The remarkable stability of the Zr-89-DOTA complex has been shown in recent literature. The formation of this complex appears to require Zr-89-chloride as the complexation precursor rather than the more conventional Zr-89-oxalate. In this work we present a method for the direct isolation of Zr-89-chloride from irradiated Y-nat foils.
Methods: Zr-89, Zr-88, and Y-88 were prepared by 16 MeV proton irradiation of Y-nat foils and used for batch-extraction based equilibrium coefficient measurements for TBP and UTEVA resin. Radionuclidically pure Zr-89 was prepared by 14 MeV proton-irradiation of Y-nat foils. These foils were dissolved in concentrated HCl, trapped on columns of TBP or UTEVA resin, and Zr-89-chloride was eluted in <1 mL of 0.1 M HCl. For purposes of comparison, conventionally-isolated Zr-89-oxalate was converted to Zr-89-chloride by trapping, rinsing, and elution from a QMA cartridge into 1 M HCl. Trace metal analysis was performed on the resulting Zr-89 products.
Results: Equilibrium coefficients for Y and Zr were similar between UTEVA and TBP resins across all HCl concentrations. K-d values of <10(-1) mL/g were observed for Y across all HCl concentrations. K-d values of >10(3) mL/g were observed at HCl concentrations >9 M for Zr, falling to K-d values of <10(0) mL/g at low HCl concentrations. Zr-89-chloride was recovered from small columns of TBP in <1 mL of 0.1 M HCl with an overall recovery efficiency of 89 +/- 3% (n = 3). An average Y/Zr separation factor of 1.5 x 10(5) (n = 3) was obtained. Trace metal impurities, notably Fe, were higher in TBP-isolated Zr-89-chloride compared with Zr-89-chloride prepared using the conventional two-step procedure.
Conclusion: TBP-functionalized resin appears promising for the direct isolation of Zr-89-chloride from irradiated Y-nat targets. Excellent Zr-89 recovery efficiencies were obtained, and chemical purity was sufficient for proof-of-concept chelation studies. (C) 2018 Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- Evaluation of a chloride-based Zr-89 isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin
- Creators
- Stephen A. Graves - Univ Iowa, Dept Radiat Oncol, 200 Hawkins Dr, Iowa City, IA 52242 USAChristopher Kutyreff - University of Wisconsin–MadisonKendall E. Barrett - University of Wisconsin–MadisonReinier Hernandez - University of Wisconsin–MadisonPaul A. Ellison - University of Wisconsin–MadisonSteffen Happel - TrisKem International, 3 rue des champs Geons, 35170 Bruz, France.Eduardo Aluicio-Sarduy - University of Wisconsin–MadisonTodd E. Barnhart - University of Wisconsin–MadisonRobert J. Nickles - University of Wisconsin–MadisonJonathan W. Engle - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Nuclear medicine and biology, Vol.64-65, pp.1-7
- Publisher
- Elsevier
- DOI
- 10.1016/j.nucmedbio.2018.06.003
- PMID
- 30015090
- PMCID
- PMC6153039
- ISSN
- 0969-8051
- eISSN
- 1872-9614
- Number of pages
- 7
- Grant note
- University of Wisconsin - Madison T32CA009206 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) T32-CA009206 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 09/01/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
- Record Identifier
- 9984383912902771
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