Evaluation of a motion-robust 2D chemical shift-encoded technique for R2and field map quantification in ferumoxytol-enhanced MRI of the placenta in pregnant rhesus macaques

Ante Zhu; Scott B. Reeder; Kevin M. Johnson; Sydney M. Nguyen; Thaddeus G. Golos; Ann Shimakawa; Matthias R. Muehler; Christopher J. Francois; Ian M. Bird; Sean B. Fain; Dinesh M. Shah; Oliver Wieben; Diego Hernando

doi:10.1002/jmri.26849

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Evaluation of a motion-robust 2D chemical shift-encoded technique for R2and field map quantification in ferumoxytol-enhanced MRI of the placenta in pregnant rhesus macaques

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Evaluation of a motion-robust 2D chemical shift-encoded technique for R2and field map quantification in ferumoxytol-enhanced MRI of the placenta in pregnant rhesus macaques

Ante Zhu, Scott B. Reeder, Kevin M. Johnson, Sydney M. Nguyen, Thaddeus G. Golos, Ann Shimakawa, Matthias R. Muehler, Christopher J. Francois, Ian M. Bird, Sean B. Fain, …

Journal of magnetic resonance imaging, Vol.51(2), pp.580-592

02/01/2020

DOI: 10.1002/jmri.26849

PMCID: PMC7839098

PMID: 31276263

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https://www.ncbi.nlm.nih.gov/pmc/articles/7839098View

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Abstract

Background 3D chemical shift-encoded (CSE)-MRI techniques enable assessment of ferumoxytol concentration but are unreliable in the presence of motion. Purpose To evaluate a motion-robust 2D-sequential CSE-MRI for R2* and B0 mapping in ferumoxytol-enhanced MRI of the placenta. Study Type Prospective. Animal Model Pregnant rhesus macaques. Field Strength/Sequence 3.0T/CSE-MRI. Assessment 2D-sequential CSE-MRI was compared with 3D respiratory-gated CSE-MRI in placental imaging of 11 anesthetized animals at multiple timepoints before and after ferumoxytol administration, and in ferumoxytol phantoms (0 mu g/mL-440 mu g/mL). Motion artifacts of CSE-MRI in 10 pregnant women without ferumoxytol administration were assessed retrospectively by three blinded readers (4-point Likert scale). The repeatability of CSE-MRI in seven pregnant women was also prospectively studied. Statistical Tests Placental R2* and boundary B0 field measurements (Delta B0) were compared between 2D-sequential and 3D respiratory-gated CSE-MRI using linear regression and Bland-Altman analysis. Results In phantoms, a slope of 0.94 (r(2) = 0.99, concordance correlation coefficient rho = 0.99), and bias of -4.8 s(-1) (limit of agreement [LOA], -41.4 s(-1), +31.8 s(-1)) in R2*, and a slope of 1.07 (r(2) = 1.00, rho = 0.99) and bias of 11.4 Hz (LOA -12.0 Hz, +34.8 Hz) in Delta B0 were obtained in 2D CSE-MRI compared with 3D CSE-MRI for reference R2* <= 390 s(-1). In animals, a slope of 0.92 (r(2) = 0.97, rho = 0.98) and bias of -2.2 s(-1) (LOA -55.6 s(-1), +51.3 s(-1)) in R2*, and a slope of 1.05 (r(2) = 0.95, rho = 0.97) and bias of 0.4 Hz (LOA -9.0 Hz, +9.7 Hz) in Delta B0 were obtained. In humans, motion-impaired R2* maps in 3D CSE-MRI (Reader 1: 1.8 +/- 0.6, Reader 2: 1.3 +/- 0.7, Reader 3: 1.9 +/- 0.6), while 2D CSE-MRI was motion-free (Reader 1: 2.9 +/- 0.3, Reader 2: 3.0 +/- 0, Reader 3: 3.0 +/- 0). A mean difference of 0.66 s(-1) and coefficient of repeatability of 9.48 s(-1) for placental R2* were observed in the repeated 2D CSE-MRI. Data Conclusion 2D-sequential CSE-MRI provides accurate R2* and B0 measurements in ferumoxytol-enhanced placental MRI of animals in the presence of respiratory motion, and motion-robustness in human placental imaging. Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2020;51:580-592.

Life Sciences & Biomedicine

Radiology, Nuclear Medicine & Medical Imaging

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Title: Subtitle: Evaluation of a motion-robust 2D chemical shift-encoded technique for R2and field map quantification in ferumoxytol-enhanced MRI of the placenta in pregnant rhesus macaques
Creators: Ante Zhu - University of Wisconsin–Madison
Scott B. Reeder - University of Wisconsin–Madison
Kevin M. Johnson - University of Wisconsin–Madison
Sydney M. Nguyen - University of Wisconsin–Madison
Thaddeus G. Golos - University of Wisconsin–Madison
Ann Shimakawa
Matthias R. Muehler - University of Wisconsin–Madison
Christopher J. Francois - University of Wisconsin–Madison
Ian M. Bird - University of Wisconsin–Madison
Sean B. Fain - University of Wisconsin–Madison
Dinesh M. Shah - University of Wisconsin–Madison
Oliver Wieben - University of Wisconsin–Madison
Diego Hernando - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Journal of magnetic resonance imaging, Vol.51(2), pp.580-592
DOI: 10.1002/jmri.26849
PMID: 31276263
PMCID: PMC7839098
NLM abbreviation: J Magn Reson Imaging
ISSN: 1053-1807
eISSN: 1522-2586
Publisher: Wiley
Number of pages: 13
Grant note: R01 DK117354; K24 DK102595; R01 DK100651 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) P51 OD011106 / NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U01 HD087216; T32 HD041921 / NICHD NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Language: English
Date published: 02/01/2020
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
Record Identifier: 9984275058202771

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