Journal article
Evaluation of a novel supplement to reduce blood glucose through the use of a modified oral glucose tolerance test
American journal of translational research, Vol.3(2), pp.219-225
02/2011
PMCID: PMC3056567
PMID: 21416063
Abstract
Elevated blood glucose is a major component in metabolic syndrome and pre-diabetes, sometimes leading to type 2 diabetes mellitus (DM II). Additionally, it may lead to adipose deposits when left elevated for long periods. The epidemiology of DM II clearly shows that uncontrolled blood glucose levels leads to many adverse conditions including heart disease, retinal damage, renal failure, erectile dysfunction, and other significant medical conditions. Here we conducted a single-center, prospective, randomized, double-blinded, placebo-controlled, parallel-group- clinical trial of a nutraceutical supplement vs. placebo to measure its glucose lowering effect in generally healthy adults before and after a simple sugars meal. Subjects reported to the test clinic on multiple days to receive placebo or treatment, a simple sugars meal, as well as pre-and postprandial blood glucose measurement (modified oral glucose tolerance test). Each subject served as his or her own control and thirty-one subjects completed the trial with at least one oral glucose tolerance test (OGTT) with the nutraceutical supplement and placebo. Statistical analysis revealed the nutraceutical supplement significantly lowered postprandial glucose levels by 36% and 59% at 45 and 60 minutes, respectively (***P<.001). The study was limited by its composition of primarily overweight females. Future studies will be required over longer periods in more heterogeneous and larger groups to determine the long-term effect of this supplement on blood glucose levels in terms of prophylaxis or treatment for DM II.
Details
- Title: Subtitle
- Evaluation of a novel supplement to reduce blood glucose through the use of a modified oral glucose tolerance test
- Creators
- Adam J SmithBrian GiuntaR Douglas ShytleJames M Blum
- Resource Type
- Journal article
- Publication Details
- American journal of translational research, Vol.3(2), pp.219-225
- PMID
- 21416063
- PMCID
- PMC3056567
- ISSN
- 1943-8141
- eISSN
- 1943-8141
- Grant note
- R01 MH098737 / NIMH NIH HHS
- Language
- English
- Date published
- 02/2011
- Academic Unit
- Anesthesia
- Record Identifier
- 9984295917402771
Metrics
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