Journal article
Evaluation of a scheme for establishing and maintaining dosage of theophylline in ambulatory patients with chronic asthma
The Journal of pediatrics, Vol.109(2), pp.351-354
1986
DOI: 10.1016/S0022-3476(86)80403-6
PMID: 3734974
Abstract
To assess the utility of a dose-titration scheme for determining maintenance theophylline requirements, dose requirements and stability of serum concentrations were examined using 3537 serum determinations from 1073 patients with chronic asthma during a 5-year period. When the dosing scheme was followed, 78% of initial serum concentrations were within the target range of 10 to 20 μg/ml; the mean number of measurements to attain this range was 1.3. Among 404 of these patients prospectively questioned, adverse effects were not present in all 41 whose initial serum concentration was <10μg/ml, occurred in eight of 296 patients when serum concentrations were between 10 and 20 μg/ml, and were present in 21 of 67 when concentrations were >20 μg/ml. After final dose adjustment, mean dose requirements among those who attained serum concentrations of 10 to 20 μg/ml averaged 22 mg/kg/day in 1- to 9-year-old children, 20 mg/kg/day in 9- to 12-year-old children, 18 mg/kg/day in 12- to 16 year-old children, and 13 mg/kg/day in the 94 patients older than 16 years of age. Repeat serum concentrations after 3 months to 2 years showed 66% remaining within the 10 to 20 μg/ml range and another 15% between 7.5 and 10 μg/ml; 9% were >20 μg/ml, and none >30 μg/ml. Thus the dosing scheme produces serum concentrations in the usual therapeutic range with a minimum of samples and few side effects; most patients maintained acceptably stable blood levels.
Details
- Title: Subtitle
- Evaluation of a scheme for establishing and maintaining dosage of theophylline in ambulatory patients with chronic asthma
- Creators
- Gary Milavetz - University of IowaLeigh M. Vaughan - University of IowaMiles M. Weinberger - University of IowaLeslie Hendeles - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.109(2), pp.351-354
- Publisher
- Mosby, Inc
- DOI
- 10.1016/S0022-3476(86)80403-6
- PMID
- 3734974
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Language
- English
- Date published
- 1986
- Academic Unit
- Pharmacy; Stead Family Department of Pediatrics; Pharmacy Practice and Science
- Record Identifier
- 9984365893202771
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