Journal article
Evaluation of amphotericin B and flucytosine in combination against Candida albicans and Cryptococcus neoformans using time-kill methodology
Diagnostic microbiology and infectious disease, Vol.41(3), pp.121-126
2001
DOI: 10.1016/S0732-8893(01)00297-8
PMID: 11750164
Abstract
In this study, time-kill methods were used to evaluate the antifungal activity of amphotericin B and flucytosine, alone and in combination, against six isolates of
Candida albicans and
Cryptococcus neoformans. Five regimens were tested against each isolate: (1) flucytosine, (2) low-dose amphotericin B, (3) high-dose amphotericin B, (4) low-dose amphotericin B plus flucytosine, and (5) high-dose amphotericin B plus flucytosine. Low-dose amphotericin B and flucytosine, administered alone and simultaneously, demonstrated fungistatic activity against all sample isolates except
C. albicans 90028, in which fungicidal activity was detected with the combination. High-dose amphotericin B, alone and in combination, resulted in a rapid fungicidal effect in all isolates. In both the low and high-dose combinations, indifferent activity was demonstrated against all tested isolates. By virtue of the absence of an antagonistic interaction between these two agents, complementary pharmacokinetic profiles, and non-overlapping toxicities, continued clinical use of these agents in combination may be considered.
Details
- Title: Subtitle
- Evaluation of amphotericin B and flucytosine in combination against Candida albicans and Cryptococcus neoformans using time-kill methodology
- Creators
- Douglas J. Keele - University of IowaVeronica C. DeLallo - University of IowaRussell E. Lewis - University of HoustonErika J. Ernst - University of IowaMichael E. Klepser - Ferris State University
- Resource Type
- Journal article
- Publication Details
- Diagnostic microbiology and infectious disease, Vol.41(3), pp.121-126
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0732-8893(01)00297-8
- PMID
- 11750164
- ISSN
- 0732-8893
- eISSN
- 1879-0070
- Language
- English
- Date published
- 2001
- Academic Unit
- Pharmacy Practice and Science
- Record Identifier
- 9984366031102771
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