Journal article
Evaluation of baroreceptor reflex function in the chronic mild stress rodent model of depression
Psychosomatic medicine, Vol.70(4), pp.435-443
05/2008
DOI: 10.1097/PSY.0b013e31816ff7dd
PMCID: PMC3399455
PMID: 18480191
Abstract
Objective: There is a bidirectional relationship between mood disorders (e.g., depression) and altered cardiovascular regulation (e.g., heart disease); however, the precise causal and/or common mechanisms underlying this association are unclear. In previous studies, we have noted indications of altered sympathetic drive to the heart in rats that exhibit anhedonia, an operational sign of depression induced by subjecting the animals to a series of mild and unpredictable stressors (chronic mild stress (CMS) rodent model of depression). The purpose of the present study was to more fully characterize baroreceptor reflex function in rats with experimentally induced depression. Methods: Male, Sprague-Dawley rats were exposed to either 4 weeks of mild, unpredictable stressors (CMS group) or standard housing conditions (control group). Depression-like behavior, resting hemodynamic and cardiac parameters, and baroreceptor reflex function were investigated in all animals after the CMS period. Results: CMS produced anhedonia, evidenced by reduced sucrose intake and sucrose preference, as well as elevated resting heart rate (HR), slightly elevated blood pressure, and reduced HR variability. These animals also exhibited significantly attenuated sympathoexcitatory responses to hypotension, and an elevation of basal sympathetic nerve activity. Conclusions: These findings suggest that CMS is associated with altered sympathoexcitatory responses after baroreceptor unloading and provide further insights into potential common mechanisms underlying the association of depression and altered cardiovascular control. Copyright © 2008 by the American Psychosomatic Society.
Details
- Title: Subtitle
- Evaluation of baroreceptor reflex function in the chronic mild stress rodent model of depression
- Creators
- Angela J Grippo - Department of Psychology, University of Iowa, Iowa City, Iowa 52242 Department of Integrative Physiology, University of Iowa, Iowa City, Iowa 52242 Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242 Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242Julia A Moffitt - Department of Psychology, University of Iowa, Iowa City, Iowa 52242 Department of Integrative Physiology, University of Iowa, Iowa City, Iowa 52242 Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242 Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242Alan Kim Johnson - Department of Psychology, University of Iowa, Iowa City, Iowa 52242 Department of Integrative Physiology, University of Iowa, Iowa City, Iowa 52242 Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242 Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Psychosomatic medicine, Vol.70(4), pp.435-443
- DOI
- 10.1097/PSY.0b013e31816ff7dd
- PMID
- 18480191
- PMCID
- PMC3399455
- NLM abbreviation
- Psychosom Med
- ISSN
- 0033-3174
- eISSN
- 1534-7796
- Language
- English
- Date published
- 05/2008
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
- Record Identifier
- 9984213416302771
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