Evaluation of cerebral electrical activity and cardiac output after patent ductus arteriosus ligation in preterm infants

A T F S Leslie; A Jain; A El-Khuffash; M Keyzers; S Rogerson; P J McNamara

doi:10.1038/jp.2013.85

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Evaluation of cerebral electrical activity and cardiac output after patent ductus arteriosus ligation in preterm infants

Journal article

Peer reviewed

Evaluation of cerebral electrical activity and cardiac output after patent ductus arteriosus ligation in preterm infants

A T F S Leslie, A Jain, A El-Khuffash, M Keyzers, S Rogerson and P J McNamara

Journal of perinatology, Vol.33(11), pp.861-866

11/2013

DOI: 10.1038/jp.2013.85

PMID: 23887196

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Abstract

To characterize and investigate the relationship between systemic blood flow and pre- and postoperative cerebral electrical activity in preterm neonates undergoing patent ductus arteriosus (PDA) ligation. A prospective observational study was conducted in 17 preterm neonates undergoing PDA ligation. All infants had amplitude-integrated electroencephalography (aEEG) recorded continuously from 4 h preoperatively to 24 h postoperatively. Targeted neonatal echocardiography was performed to evaluate myocardial performance and systemic blood flow at four sequential time points: preoperatively; 1, 8 and 24 h postoperatively. PDA ligation was followed by a fall in the lower border of the aEEG trace lower left ventricular output, but recovery of diastolic flow in the middle cerebral artery. Altered lower margin was associated with gestational age and PDA diameter on univariate analysis, but not with low cardiac output. PDA ligation was associated with altered cerebral electrical activity, although these changes were not related to low cardiac output state.

Ductus Arteriosus, Patent - surgery

Infant, Premature, Diseases - physiopathology

Echocardiography

Prospective Studies

Brain - physiopathology

Humans

Cardiac Output

Postoperative Period

Male

Infant, Premature, Diseases - surgery

Gestational Age

Infant, Premature

Electrocardiography

Female

Ductus Arteriosus, Patent - physiopathology

Preoperative Period

Details

Title: Subtitle: Evaluation of cerebral electrical activity and cardiac output after patent ductus arteriosus ligation in preterm infants
Creators: A T F S Leslie - Division of Neonatology, Department of Pediatrics, Federal University of Sao Paulo, Sao Paulo, Brazil
A Jain
A El-Khuffash
M Keyzers
S Rogerson
P J McNamara
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.33(11), pp.861-866
DOI: 10.1038/jp.2013.85
PMID: 23887196
NLM abbreviation: J Perinatol
ISSN: 0743-8346
eISSN: 1476-5543
Language: English
Date published: 11/2013
Academic Unit: Stead Family Department of Pediatrics; Neonatology; Internal Medicine
Record Identifier: 9984093331502771

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