Logo image
Evaluation of disk diffusion and Etest compared to broth microdilution for antifungal susceptibility testing of posaconazole against clinical isolates of filamentous fungi
Journal article   Open access   Peer reviewed

Evaluation of disk diffusion and Etest compared to broth microdilution for antifungal susceptibility testing of posaconazole against clinical isolates of filamentous fungi

Shawn A Messer, Daniel J Diekema, Richard J Hollis, Linda B Boyken, Shailesh Tendolkar, Jennifer Kroeger and Michael A Pfaller
Journal of clinical microbiology, Vol.45(4), pp.1322-1324
04/2007
DOI: 10.1128/JCM.02450-06
PMCID: PMC1865846
PMID: 17267623
url
https://doi.org/10.1128/JCM.02450-06View
Published (Version of record) Open Access

Abstract

We performed Etest, disk diffusion, and broth microdilution susceptibility testing of posaconazole against 146 clinical isolates of filamentous fungi. By using provisional breakpoints for comparison purposes only, categorical agreement between the results of the agar-based methods and those of broth microdilution were 96 to 98%, with no very major errors. These agar-based methods hold promise as simple and reliable methods for determining the posaconazole susceptibilities of filamentous fungi.
Antifungal Agents - pharmacology Triazoles - pharmacology Fungi - drug effects Humans Fungi - isolation & purification Mycoses - microbiology Microbial Sensitivity Tests - methods

Details

Metrics

Logo image