Evaluation of heparinized syringes for measuring newborn metabolites in neonates with a central arterial line

Kelli K Ryckman; Abhismitha Ramesh; Hyunkeun Cho; Scott P Oltman; Elizabeth E Rogers; John M Dagle; Laura L Jelliffe-Pawlowski

doi:10.1016/j.clinbiochem.2021.10.007

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Evaluation of heparinized syringes for measuring newborn metabolites in neonates with a central arterial line

Journal article

Open access

Peer reviewed

Evaluation of heparinized syringes for measuring newborn metabolites in neonates with a central arterial line

Kelli K Ryckman, Abhismitha Ramesh, Hyunkeun Cho, Scott P Oltman, Elizabeth E Rogers, John M Dagle and Laura L Jelliffe-Pawlowski

Clinical biochemistry, Vol.99, pp.78-81

01/2022

DOI: 10.1016/j.clinbiochem.2021.10.007

PMCID: PMC8671267

PMID: 34688611

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https://doi.org/10.1016/j.clinbiochem.2021.10.007View

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Abstract

Newborn metabolic screening is emerging as a novel method for predicting neonatal morbidity and mortality in neonates born very preterm (<32 weeks gestation). The purpose of our study was to determine if blood collected by an electrolyte-balanced dry lithium heparin syringe, as is routine for blood gas measurements, affects targeted metabolite and biomarker levels. Two blood samples (one collected with a heparinized syringe and the other with a non-heparinized syringe) were obtained at the same time from 20 infants with a central arterial line and tested for 49 metabolites and biomarkers using standard procedures for newborn screening. Overall, the median metabolite levels did not significantly differ by syringe type. However, there was wide variability, particularly for amino acids and immunoreactive trypsinogen, for individual paired samples and therefore, consideration should be given to sample collection when using these metabolites in prediction models of neonatal morbidity and mortality.

Biomarkers - blood

Blood Specimen Collection

Central Venous Catheters

Female

Heparin - pharmacology

Humans

Infant, Newborn

Male

Neonatal Screening

Syringes

Details

Title: Subtitle: Evaluation of heparinized syringes for measuring newborn metabolites in neonates with a central arterial line
Creators: Kelli K Ryckman - University of Iowa, Department of Epidemiology, United States. Electronic address: Kelli-ryckman@uiowa.edu
Abhismitha Ramesh - University of Iowa, Department of Epidemiology, United States
Hyunkeun Cho - University of Iowa, Department of Biostatistics, United States
Scott P Oltman - University of California, San Francisco, Department of Epidemiology & Biostatistics, United States; UCSF California Preterm Birth Initiative, United States
Elizabeth E Rogers - UCSF California Preterm Birth Initiative, United States; University of California San Francisco, Department of Pediatrics, United States
John M Dagle - University of Iowa, Department of Pediatrics, United States
Laura L Jelliffe-Pawlowski - University of California, San Francisco, Department of Epidemiology & Biostatistics, United States; UCSF California Preterm Birth Initiative, United States
Resource Type: Journal article
Publication Details: Clinical biochemistry, Vol.99, pp.78-81
DOI: 10.1016/j.clinbiochem.2021.10.007
PMID: 34688611
PMCID: PMC8671267
NLM abbreviation: Clin Biochem
ISSN: 0009-9120
eISSN: 1873-2933
Grant note: R01 HD102381 / NICHD NIH HHS
Language: English
Date published: 01/2022
Academic Unit: Stead Family Department of Pediatrics; Epidemiology; Biostatistics; Biochemistry and Molecular Biology; Neonatology
Record Identifier: 9984214821402771

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