Journal article
Evaluation of inductively heated ferromagnetic alloy implants for therapeutic interstitial hyperthermia
IEEE transactions on biomedical engineering, Vol.43(4), pp.406-413
1996
DOI: 10.1109/10.486260
PMID: 8626189
Abstract
Ferromagnetic alloys heated by magnetic induction have been investigated as interstitial hyperthermia delivery implants for over a decade, utilizing low Curie temperatures to provide thermal self-regulation. The minimally invasive method is attractive for fractionated thermal treatment of tumors which are not easily heated by focused microwave or ultrasound techniques. Past analyses of ferromagnetic seeds by other authors depict poor experimental correlation with theoretical heating predictions. Improvements in computer hardware and commercially available finite element analysis software have simplified the analysis of inductively heated thermal seeds considerably. This manuscript examines end effects of finite length implants and nonlinear magnetic material properties to account for previous inconsistencies. Two alloys, Ni-28 wt% Cu (NiCu) and Pd-6.15 wt% Co (PdCo), were used for comparison of theoretical and experimental calorimetric results. Length to diameter (L/d) ratios of over 20 for cylindrical seeds are necessary for minimization of end effects. Magnetic properties tested for alloys of NiCu and PdCo illustrate considerable nonlinearity of these materials in field strength ranges used for induction heating. Field strength dependent magnetic permeabilities and calorimetric data illustrate that more detailed material information must be included to accurately estimate induction power loss for these implants.
Details
- Title: Subtitle
- Evaluation of inductively heated ferromagnetic alloy implants for therapeutic interstitial hyperthermia
- Creators
- Joseph A Paulus - Department of Pathology, University of Iowa, 27 Medical Labs, Iowa City, IA 52242, United StatesJon S Richardson - Department of Pathology, University of Iowa, 27 Medical Labs, Iowa City, IA 52242, United StatesRobert D Tucker - Department of Pathology, University of Iowa, 27 Medical Labs, Iowa City, IA 52242, United StatesJoon B Park - Department of Pathology, University of Iowa, 27 Medical Labs, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- IEEE transactions on biomedical engineering, Vol.43(4), pp.406-413
- Publisher
- Institute of Electrical and Electronics Engineers; New York, NY
- DOI
- 10.1109/10.486260
- PMID
- 8626189
- ISSN
- 0018-9294
- eISSN
- 1558-2531
- Language
- English
- Date published
- 1996
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pathology
- Record Identifier
- 9984047624602771
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