Evaluation of locally recurrent pelvic malignancy: performance of T2- and diffusion-weighted MRI with image fusion

Akihiro Nishie; Alan H Stolpen; Masao Obuchi; David M Kuehn; Aaron Dagit; Kelli Andresen

doi:10.1002/jmri.21486

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Evaluation of locally recurrent pelvic malignancy: performance of T2- and diffusion-weighted MRI with image fusion

Journal article

Peer reviewed

Evaluation of locally recurrent pelvic malignancy: performance of T2- and diffusion-weighted MRI with image fusion

Akihiro Nishie, Alan H Stolpen, Masao Obuchi, David M Kuehn, Aaron Dagit and Kelli Andresen

Journal of magnetic resonance imaging, Vol.28(3), pp.705-713

09/2008

DOI: 10.1002/jmri.21486

PMID: 18777555

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Abstract

To evaluate the performance of T2- and diffusion-weighted magnetic resonance imaging (MRI) with image fusion for detection of locally recurrent pelvic malignancy. The study group consisted of 28 patients (27 female, 1 male) who underwent pelvic MRI at 1.5 T after treatment of pelvic malignancy. MR images were reviewed independently by three blinded readers. The performance of the four sequences for detecting local recurrence was evaluated using receiver operating characteristic analysis: T2-weighted fast spin-echo (FSE), diffusion-weighted echo-planar imaging (DWI), dynamic contrast-enhanced (DCE) fat-suppressed T1-weighted spoiled gradient echo (SPGR), and T2-DWI with image fusion, the latter created using OsiriX Medical Imaging Software. Local recurrence was confirmed at biopsy in 16 patients. Twelve patients showed no evidence of recurrence on two consecutive MRI studies. The Az value for T2-DWI with image fusion (0.949) was statistically greater than that for T2-weighted FSE (0.849) (P<0.05). The sensitivity and specificity was 87.5% and 47.2%, respectively, for T2-weighted FSE, 100.0% and 50.0% for DWI, 95.8% and 58.3% for DCE fat-suppressed T1-weighted SPGR, and 93.8% and 72.2% for T2-DWI with image fusion. For depicting locally recurrent pelvic malignancy, T2-DWI with image fusion outperforms standard T2-weighted FSE and DWI and is comparable to DCE fat-suppressed T1-weighted SPGR.

Single-Blind Method

Reproducibility of Results

Prognosis

Neoplasm Recurrence, Local - prevention & control

Humans

Image Interpretation, Computer-Assisted - methods

Middle Aged

Male

Pelvic Neoplasms - diagnosis

Treatment Outcome

Neoplasm Recurrence, Local - diagnosis

Subtraction Technique

Pelvic Neoplasms - therapy

Sensitivity and Specificity

Adult

Female

Aged

Retrospective Studies

Diffusion Magnetic Resonance Imaging - methods

Details

Title: Subtitle: Evaluation of locally recurrent pelvic malignancy: performance of T2- and diffusion-weighted MRI with image fusion
Creators: Akihiro Nishie - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. anishie@radiol.med.kyushu-u.ac.jp
Alan H Stolpen
Masao Obuchi
David M Kuehn
Aaron Dagit
Kelli Andresen
Resource Type: Journal article
Publication Details: Journal of magnetic resonance imaging, Vol.28(3), pp.705-713
DOI: 10.1002/jmri.21486
PMID: 18777555
NLM abbreviation: J Magn Reson Imaging
ISSN: 1053-1807
eISSN: 1522-2586
Publisher: United States
Language: English
Date published: 09/2008
Academic Unit: Radiology; Urology; Internal Medicine
Record Identifier: 9984051739602771

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