Journal article
Evaluation of retinal nerve fibre layer thickness as a possible measure of diabetic retinal neurodegeneration in the EPIC-Norfolk Eye Study
British journal of ophthalmology, Vol.107(5), pp.705-711
05/2023
DOI: 10.1136/bjophthalmol-2021-319853
PMCID: PMC9460960
PMID: 34952836
Abstract
Markers to clinically evaluate structural changes from diabetic retinal neurodegeneration (DRN) have not yet been established. To study the potential role of peripapillary retinal nerve fibre layer (pRNFL) thickness as a marker for DRN, we evaluated the relationship between diabetes, as well as glycaemic control irrespective of diabetes status and pRNFL thickness.
Leveraging data from a population-based cohort, we used general linear mixed models (GLMMs) with a random intercept for patient and eye to assess the association between pRNFL thickness (measured using GDx) and demographic, systemic and ocular parameters after adjusting for typical scan score. GLMMs were also used to determine: (1) the relationship between: (A) glycated haemoglobin (HbA1c) irrespective of diabetes diagnosis and pRNFL thickness, (B) diabetes and pRNFL thickness and (2) which quadrants of pRNFL may be affected in participants with diabetes and in relation to HbA1c.
7076 participants were included. After controlling for covariates, inferior pRNFL thickness was 0.94 µm lower (95% CI -1.28 µm to -0.60 µm), superior pRNFL thickness was 0.83 µm lower (95% CI -1.17 µm to -0.49 µm) and temporal pRNFL thickness was 1.33 µm higher (95% CI 0.99 µm to 1.67 µm) per unit increase in HbA1c. Nasal pRNFL thickness was not significantly associated with HbA1c (p=0.23). Similar trends were noted when diabetes was used as the predictor.
Superior and inferior pRNFL was significantly thinner among those with higher HbA1c levels and/or diabetes, representing areas of the pRNFL that may be most affected by diabetes.
Details
- Title: Subtitle
- Evaluation of retinal nerve fibre layer thickness as a possible measure of diabetic retinal neurodegeneration in the EPIC-Norfolk Eye Study
- Creators
- Sidra Zafar - Johns Hopkins HospitalKristen A Staggers - Baylor College of MedicineJie Gao - Baylor College of MedicineYao Liu - University of Wisconsin–MadisonPraveen J Patel - Moorfields Eye Hospital NHS Foundation TrustPaul J Foster - Moorfields Eye Hospital NHS Foundation TrustBenjamin J Frankfort - Baylor College of MedicineMichael Abramoff - University of Iowa, Ophthalmology and Visual SciencesCharles G Minard - Baylor College of MedicineAlasdair Warwick - MRC Epidemiology UnitAnthony P Khawaja - MRC Epidemiology UnitRoomasa Channa - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- British journal of ophthalmology, Vol.107(5), pp.705-711
- DOI
- 10.1136/bjophthalmol-2021-319853
- PMID
- 34952836
- PMCID
- PMC9460960
- NLM abbreviation
- Br J Ophthalmol
- ISSN
- 0007-1161
- eISSN
- 1468-2079
- Grant note
- DOI: 10.13039/100000053, name: National Eye Institute, award: 1K23EY030911-01; name: Department of Ophthalmology and Visual Sciences from Research to Prevent Blindness, Inc, award: None
- Language
- English
- Electronic publication date
- 12/24/2021
- Date published
- 05/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Fraternal Order of Eagles Diabetes Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984204108602771
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