Logo image
Back
Evaluation of salivary biomarker profiles following non-surgical management of chronic periodontitis
Journal article   Open access   Peer reviewed

Evaluation of salivary biomarker profiles following non-surgical management of chronic periodontitis

S. Prakasam and M. Srinivasan
Oral diseases, Vol.20(2), pp.171-177
03/01/2014
DOI: 10.1111/odi.12085
PMID: 23496245
url
https://doi.org/10.1111/odi.12085View
Published (Version of record) Open Access

Abstract

ObjectivesSoluble toll-like receptor-2 (sTLR-2) and cytokines in saliva were assessed as clinical markers for chronic periodontitis in a longitudinal study. Materials and MethodsUnstimulated whole saliva was collected from 20 periodontally healthy individuals and 20 patients with chronic periodontitis at diagnosis and at 1 and 6weeks following scaling and root planing (SRP). Biomarkers including the cytokines (IL-4, IL-6, IL-10, and IL-17), sTLR-2, and sCD14 in saliva were measured by enzyme-linked immunosorbent assay. Mann-Whitney U-test and Student's t-test were used to determine the significance between healthy and chronic periodontitis groups and that between pre- and post-SRP samples, respectively. ResultsSalivary sTLR-2, IL-17, and IL-10 levels were significantly lower and those of sCD14, IL-6, and IL-4 were significantly higher in patients with chronic periodontitis as compared with healthy controls. Furthermore, sTLR-2 and IL-4 in saliva reached levels comparable to those of healthy individuals at 6-week re-evaluation visit, implicating a correlation of the two markers with the disease process. ConclusionsOur data suggest that salivary sTLR-2 is a potential prognostic or maintenance marker for chronic periodontitis. The observed variability of salivary cytokines is consistent with the role of these cytokines in the progression of chronic periodontitis.
 Dentistry, Oral Surgery & Medicine Life Sciences & Biomedicine Science & Technology

Details

Metrics

3 Record Views
65 Times Cited - Web of Science
Logo image