Evaluation of symptom relief, nasal airflow, nasal cytology, and acceptability of two formulations of flunisolide nasal spray in patients with perennial allergic rhinitis

E. O MELTZER; H. A ORGEL; J. H VAN BAVEL; R. K BUSH; J. R HALTOM; W. J METZGER; B. A MOSS; D. Q MITCHELL; Z. K BALLAS; J. M SELTZER; G. G SHAPIRO

Journal article

Evaluation of symptom relief, nasal airflow, nasal cytology, and acceptability of two formulations of flunisolide nasal spray in patients with perennial allergic rhinitis

E. O MELTZER, H. A ORGEL, J. H VAN BAVEL, R. K BUSH, J. R HALTOM, W. J METZGER, B. A MOSS, D. Q MITCHELL, Z. K BALLAS, J. M SELTZER, …

Annals of allergy, Vol.64(6), pp.536-540

1990

PMID: 2189319

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Abstract

A new formulation of intranasal flunisolide containing less propylene glycol was compared with the original formulation for efficacy and acceptability in more than 200 patients with symptoms of perennial allergic rhinitis. In this multicenter, randomized, double-blind, parallel group study, symptomatic patients were treated with either the new or the original formulation of 0.025% solution of intranasal flunisolide for 4 weeks to provide 200 μg flunisolide daily. Both formulations were highly effective in decreasing symptom scores as evident from patients diary reports before and after treatment (P < .001). Similarly, nasal airflow was improved with each treatment as measured by anterior rhinomanometry (P < .0002) and the number of patients with nasal eosinophilia decreased (P < .01). Finally, fewer patients using the new formulation reported nasal burning or stinging and the acceptability rating of the new formulation was higher.

Biological and medical sciences

Medical sciences

Ent. Stomatology

Pharmacology. Drug treatments

Details

Title: Subtitle: Evaluation of symptom relief, nasal airflow, nasal cytology, and acceptability of two formulations of flunisolide nasal spray in patients with perennial allergic rhinitis
Creators: E. O MELTZER - Res. cent., allergy asthma medical group, San Diego CA, United States
H. A ORGEL - Res. cent., allergy asthma medical group, San Diego CA, United States
J. H VAN BAVEL - Res. cent., allergy asthma medical group, San Diego CA, United States
R. K BUSH - Res. cent., allergy asthma medical group, San Diego CA, United States
J. R HALTOM - Res. cent., allergy asthma medical group, San Diego CA, United States
W. J METZGER - Res. cent., allergy asthma medical group, San Diego CA, United States
B. A MOSS - Res. cent., allergy asthma medical group, San Diego CA, United States
D. Q MITCHELL - Res. cent., allergy asthma medical group, San Diego CA, United States
Z. K BALLAS - Res. cent., allergy asthma medical group, San Diego CA, United States
J. M SELTZER - Res. cent., allergy asthma medical group, San Diego CA, United States
G. G SHAPIRO - Res. cent., allergy asthma medical group, San Diego CA, United States
Resource Type: Journal article
Publication Details: Annals of allergy, Vol.64(6), pp.536-540
Publisher: American College of Allergy and Immunology
PMID: 2189319
ISSN: 0003-4738
Language: English
Date published: 1990
Academic Unit: Immunology; Internal Medicine
Record Identifier: 9984094728102771

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