Evaluation of the Association Between Circulating IL-1β and Other Inflammatory Cytokines and Incident Atrial Fibrillation in a Cohort of Postmenopausal Women

Sofia E. Gomez; Justin Parizo; Simon Ermakov; Joseph Larson; Robert Wallace; Themistocles Assimes; Mark Hlatky; Marcia Stefanick; Marco V. Perez

doi:10.1016/j.ahj.2023.01.010

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Evaluation of the Association Between Circulating IL-1β and Other Inflammatory Cytokines and Incident Atrial Fibrillation in a Cohort of Postmenopausal Women

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Evaluation of the Association Between Circulating IL-1β and Other Inflammatory Cytokines and Incident Atrial Fibrillation in a Cohort of Postmenopausal Women

Sofia E. Gomez, Justin Parizo, Simon Ermakov, Joseph Larson, Robert Wallace, Themistocles Assimes, Mark Hlatky, Marcia Stefanick and Marco V. Perez

The American heart journal, Vol.258, p.157

01/13/2023

DOI: 10.1016/j.ahj.2023.01.010

PMCID: PMC10023332

PMID: 36646198

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10023332/pdf/nihms-1865187.pdfView

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Abstract

: Inflammatory cytokines play a role in atrial fibrillation (AF). Interleukin (IL)-1β, which is targeted in the treatment of ischemic heart disease, has not been well-studied in relation to AF. : Postmenopausal women from the Women's Health Initiative were included. Cox proportional hazards regression models were used to evaluate the association between log-transformed baseline cytokine levels and future AF incidence. Models were adjusted for body mass index, age, race, education, hypertension, diabetes, hyperlipidemia, current smoking, and history of coronary heart disease, congestive heart failure, or peripheral artery disease. : Of 16,729 women, 3,943 developed AF over an average of 8.5 years. Racial and ethnic groups included White (77.4%), Black/African-American (16.1%), Asian (2.7%), American Indian/Alaska Native (1.0%), and Hispanic (5.5%). Baseline IL-1β log continuous levels were not significantly associated with incident AF (HR 0.86 per 1 log (pg/mL) increase, p=0.24), similar to those of other inflammatory cytokines, IL-7, IL-8, IL-10, IGF-1, and TNF-α. There were significant associations between C-reactive protein (CRP) and IL-6 with incident AF. : In this large cohort of postmenopausal women, there was no significant association between IL-1β and incident AF, although downstream effectors, CRP and IL-6, were associated with incident AF.

Atrial fibrillation

Cytokines

IL-1β

inflammation

Women's Health Initiative

Details

Title: Subtitle: Evaluation of the Association Between Circulating IL-1β and Other Inflammatory Cytokines and Incident Atrial Fibrillation in a Cohort of Postmenopausal Women
Creators: Sofia E. Gomez - Stanford University
Justin Parizo - Stanford University
Simon Ermakov - University of California, San Francisco
Joseph Larson - Fred Hutch Cancer Center
Robert Wallace - University of Iowa
Themistocles Assimes - Stanford University
Mark Hlatky - Stanford University
Marcia Stefanick - Stanford University
Marco V. Perez - Stanford University
Resource Type: Journal article
Publication Details: The American heart journal, Vol.258, p.157
DOI: 10.1016/j.ahj.2023.01.010
PMID: 36646198
PMCID: PMC10023332
NLM abbreviation: Am Heart J
ISSN: 0002-8703
eISSN: 1097-6744
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000016, name: U.S. Department of Health and Human Services, award: 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, 75N92021D00005; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: 1R01HL136390-01
Language: English
Date published: 01/13/2023
Academic Unit: Epidemiology; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9984364656702771

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