Journal article
Evaluation of the Association Between Congenital Cytomegalovirus Infection and Pediatric Acute Lymphoblastic Leukemia
JAMA network open, Vol.6(1), e2250219
01/03/2023
DOI: 10.1001/jamanetworkopen.2022.50219
PMCID: PMC9856744
PMID: 36622672
Abstract
Acute lymphoblastic leukemia (ALL) is the most common form of pediatric cancer, and a leading cause of death in children. Understanding the causes of pediatric ALL is necessary to enable early detection and prevention; congenital cytomegalovirus (cCMV) has recently been identified as a potential moderate-to-strong factor associated with risk for ALL.
To compare the prevalence of cCMV infection between ALL cases and matched controls.
In this population-based case-control study of ALL cases and matched controls, cases consisted of children aged 0 to 14 years between 1987 and 2014 with an ALL diagnosis identified through the Michigan Cancer Surveillance Program and born in Michigan on or after October 1, 1987. Cancer-free controls were identified by the Michigan BioTrust for Health and matched on age, sex, and mother's race and ethnicity. Data were analyzed from November to May 2022.
cCMV infection measured by quantitative polymerase chain reaction in newborn dried blood spots.
ALL diagnosed in children aged 0 to 14 years.
A total of 1189 ALL cases and 4756 matched controls were included in the study. Bloodspots were collected from participants at birth, and 3425 (57.6%) participants were male. cCMV was detected in 6 ALL cases (0.5%) and 21 controls (0.4%). There was no difference in the odds of cCMV infection comparing ALL cases with controls (odds ratio, 1.30; 95% CI, 0.52-3.24). Immunophenotype was available for 536 cases (45.1%) and cytogenetic data for 127 (27%). When stratified by subtype characteristics, hyperdiploid ALL (74 cases) was associated with 6.26 times greater odds of cCMV infection compared with unmatched controls (95% CI, 1.44-27.19).
In this case-control study of cCMV and pediatric ALL, cCMV was associated with increased risk of hyperdiploid ALL. These findings encourage continued research.
Details
- Title: Subtitle
- Evaluation of the Association Between Congenital Cytomegalovirus Infection and Pediatric Acute Lymphoblastic Leukemia
- Creators
- Jennifer M Geris - University of MinnesotaMark R Schleiss - University of MinnesotaAnthony J Hooten - University of MinnesotaErica Langer - University of MinnesotaNelmary Hernandez-Alvarado - University of MinnesotaMichelle A Roesler - University of MinnesotaJeannette Sample - University of MinnesotaLindsay A Williams - University of MinnesotaDavid S Dickens - University of IowaRajen J Mody - Michigan MedicineYaddanapudi Ravindranath - Wayne State UniversityKate L Gowans - Beaumont HealthMatthew G Pridgeon - Van Andel InstituteLogan G Spector - University of MinnesotaHeather H Nelson - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- JAMA network open, Vol.6(1), e2250219
- DOI
- 10.1001/jamanetworkopen.2022.50219
- PMID
- 36622672
- PMCID
- PMC9856744
- NLM abbreviation
- JAMA Netw Open
- ISSN
- 2574-3805
- eISSN
- 2574-3805
- Language
- English
- Date published
- 01/03/2023
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984359720902771
Metrics
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