Journal article
Evaluation of various corrections to the standardized uptake value for diagnosis of pulmonary malignancy
Nuclear medicine communications, Vol.22(10), pp.1077-1081
10/2001
DOI: 10.1097/00006231-200110000-00004
PMID: 11567179
Abstract
Objective Standard uptake values (SUVs) are widely used for quantifying the uptake of F-fluorodeoxyglucose (F-FDG) in tumours. The objective of this study was to evaluate the accuracy of SUVs for malignancy in lung nodules/masses and to analyse the effects of tumour size, blood glucose levels and different body weight corrections on SUV.Methods One hundred and twenty-seven patients with suspicious lung lesions imaged with F-FDG positron emission tomography (PET) were studied retrospectively. Pathology results were used to establish lesion diagnosis in all cases. SUVs based on maximum pixel values were obtained by placing regions of interest around the focus of abnormal F-FDG uptake in the lungs. The SUVs were calculated using the following normalizationsbody weight (BW), lean body weight (LBW), scaled body surface area (BSA), blood glucose level (Glu) and tumour size (Tsize). Receivers operating characteristic (ROC) curves were generated to compare the accuracy of different methods of SUV calculation.Results The areas under the ROC curves for SUVBW, SUVBW+Glu, SUVLBW, SUVLBW+Glu, SUVBSA, SUVBSA+Glu and SUVBW+Tsize were 0.915, 0.912, 0.911, 0.912, 0.916, 0.909 and 0.864, respectively.Conclusion The accuracy of SUV analysis for malignancy in lung nodules/masses is not improved by correction for blood glucose or tumour size or by normalizing for body surface area or lean body weight instead of body weight.
Details
- Title: Subtitle
- Evaluation of various corrections to the standardized uptake value for diagnosis of pulmonary malignancy
- Creators
- Y MENDA - 1Department of Radiology, and 2Division of Cardiothoracic Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa; and 3Diagnostic Imaging and Radioisotope Therapy Service, VAMC Iowa City, Iowa, USAD BUSHNELLM MADSENK McLAUGHLIND KAHNK KERNSTINE
- Resource Type
- Journal article
- Publication Details
- Nuclear medicine communications, Vol.22(10), pp.1077-1081
- Publisher
- Lippincott Williams & Wilkins, Inc
- DOI
- 10.1097/00006231-200110000-00004
- PMID
- 11567179
- ISSN
- 0143-3636
- eISSN
- 1473-5628
- Language
- English
- Date published
- 10/2001
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984046829702771
Metrics
17 Record Views