Journal article
Event-Free Survival at 24 Months Is a Robust End Point for Disease-Related Outcome in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy
Journal of clinical oncology, Vol.32(10), pp.1066-1073
04/01/2014
DOI: 10.1200/JCO.2013.51.5866
PMCID: PMC3965261
PMID: 24550425
Abstract
Purpose Studies of diffuse large B-cell lymphoma (DLBCL) are typically evaluated by using a time-to-event approach with relapse, re-treatment, and death commonly used as the events. We evaluated the timing and type of events in newly diagnosed DLBCL and compared patient outcome with reference population data. Patients and Methods Patients with newly diagnosed DLBCL treated with immunochemotherapy were prospectively enrolled onto the University of Iowa/Mayo Clinic Specialized Program of Research Excellence Molecular Epidemiology Resource (MER) and the North Central Cancer Treatment Group NCCTG-N0489 clinical trial from 2002 to 2009. Patient outcomes were evaluated at diagnosis and in the subsets of patients achieving event-free status at 12 months (EFS12) and 24 months (EFS24) from diagnosis. Overall survival was compared with age- and sex-matched population data. Results were replicated in an external validation cohort from the Groupe d'Etude des Lymphomes de l'Adulte (GELA) Lymphome Non Hodgkinien 2003 (LNH2003) program and a registry based in Lyon, France. Results In all, 767 patients with newly diagnosed DLBCL who had a median age of 63 years were enrolled onto the MER and NCCTG studies. At a median follow-up of 60 months (range, 8 to 116 months), 299 patients had an event and 210 patients had died. Patients achieving EFS24 had an overall survival equivalent to that of the age- and sex-matched general population (standardized mortality ratio [SMR], 1.18; P = .25). This result was confirmed in 820 patients from the GELA study and registry in Lyon (SMR, 1.09; P = .71). Simulation studies showed that EFS24 has comparable power to continuous EFS when evaluating clinical trials in DLBCL. Conclusion Patients with DLBCL who achieve EFS24 have a subsequent overall survival equivalent to that of the age- and sex-matched general population. EFS24 will be useful in patient counseling and should be considered as an end point for future studies of newly diagnosed DLBCL.
Details
- Title: Subtitle
- Event-Free Survival at 24 Months Is a Robust End Point for Disease-Related Outcome in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy
- Creators
- Matthew J Maurer - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéHervé Ghesquières - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéJean-Philippe Jais - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéThomas E Witzig - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéCorinne Haioun - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéCarrie A Thompson - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéRichard Delarue - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéIvana N Micallef - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéFrédéric Peyrade - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéWilliam R Macon - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéThierry Jo Molina - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéNicolas Ketterer - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéSergei I Syrbu - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéOlivier Fitoussi - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéPaul J Kurtin - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéCristine Allmer - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéEmmanuelle Nicolas-Virelizier - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéSusan L Slager - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéThomas M Habermann - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéBrian K Link - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéGilles Salles - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéHervé Tilly - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la SantéJames R Cerhan - Matthew J. Maurer, Hervé Ghesquières, Thomas E. Witzig, Carrie A. Thompson, Ivana N. Micallef, William R. Macon, Paul J. Kurtin, Cristine Allmer, Susan L. Slager, Thomas M. Habermann, and James R. Cerhan, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Emmanuelle Nicolas-Virelizier, Centre Léon Bérard; Hervé Ghesquières and Gilles Salles, Université Claude Bernard, Unite Mixte de Recherche (UMR), Centre National de la Recherche Scientifique 5239, Lyon; Jean-Philippe Jais, Institut National de la Santé
- Resource Type
- Journal article
- Publication Details
- Journal of clinical oncology, Vol.32(10), pp.1066-1073
- DOI
- 10.1200/JCO.2013.51.5866
- PMID
- 24550425
- PMCID
- PMC3965261
- ISSN
- 0732-183X
- eISSN
- 1527-7755
- Language
- English
- Date published
- 04/01/2014
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9984047787402771
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