Evidence against the presence of ventricular chemoreceptors activated by hypoxia and hypercapnia

Allyn L Mark; François M Abboud; Donald D Heistad; Phillip G Schmid; U. James Johannsen

doi:10.1152/ajplegacy.1974.227.1.178

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Evidence against the presence of ventricular chemoreceptors activated by hypoxia and hypercapnia

Journal article

Peer reviewed

Evidence against the presence of ventricular chemoreceptors activated by hypoxia and hypercapnia

Allyn L Mark, François M Abboud, Donald D Heistad, Phillip G Schmid and U. James Johannsen

The American journal of physiology, Vol.227(1), pp.178-182

07/1974

DOI: 10.1152/ajplegacy.1974.227.1.178

PMID: 4843369

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Abstract

This study was performed to test the hypothesis that the Bezold Jarisch or coronary chemoreflex is activated by hypoxia and hypercapnia. The circumflex coronary artery of 10 anesthetized dogs was perfused at constant flow with: normoxic, normocapnic blood and hypoxic, hypercapnic blood (PO2, 43 ± 3 mmHg; PCO2 > 100 mmHg; pH 6.96 ± 0.13 U) while maintaining systemic normoxia and normocapnia. Reflex vascular responses were observed in innervated, perfused gracilis muscle and hindpaw. Local coronary hypoxia and hypercapnia did not produce significant reflex vascular responses although the Bezold Jarisch reflex was intact; the hypoxic, hypercapnic blood caused coronary vasodilatation; the degree of hypoxia and hypercapnia was sufficient to activate chemoreceptors as indicated by reflex vasoconstriction in muscle when carotid chemoreceptors were exposed to the hypoxic and hypercapnic blood. Vagotomy blocked hypotension produced by coronary injection of nicotine, but not that during coronary hypoxia and hypercapnia. The results indicate that the Bezold Jarisch or coronary chemoreflex is not activated by hypoxia and hypercapnia and suggest that distal coronary vessels and myocardium do not contain receptors which have the physiologic characteristics of arterial chemoreceptors.

Hypoxia

Blood Pressure

Coronary Circulation

Respiratory Insufficiency - etiology

Male

Chemoreceptor Cells - physiology

Carbon Dioxide - blood

Vagotomy

Oxygen - blood

Nicotine - pharmacology

Hypercapnia

Vagus Nerve - physiology

Animals

Dilatation

Bradycardia - etiology

Dogs

Heart Ventricles - innervation

Details

Title: Subtitle: Evidence against the presence of ventricular chemoreceptors activated by hypoxia and hypercapnia
Creators: Allyn L Mark
François M Abboud
Donald D Heistad
Phillip G Schmid
U. James Johannsen
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.227(1), pp.178-182
DOI: 10.1152/ajplegacy.1974.227.1.178
PMID: 4843369
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Publisher: American Physiological Society; United States
Language: English
Date published: 07/1974
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984025445302771

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