Journal article
Evidence for Association of Bipolar Disorder to Haplotypes in the 22q12.3 Region Near the Genes Stargazin, IFT27 and Parvalbumin
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.159B(8), pp.941-950
12/2012
DOI: 10.1002/ajmg.b.32099
PMCID: PMC3665332
PMID: 23038240
Abstract
We have previously reported genome-wide significant linkage of bipolar disorder to a region on 22q12.3 near the marker D22S278. Towards identifying the susceptibility gene, we have conducted a fine-mapping association study of the region in two independent family samples, an independent case–control sample and a genome-wide association dataset. Two hundred SNPs were first examined in a 5 Mb region surrounding the D22S278 marker in a sample of 169 families and analyzed using PLINK. The peak of association was a haplotype near the genes stargazin (CACNG2), intraflagellar transport protein homolog 27 (IFT27) and parvalbumin (PVALB;
Details
- Title: Subtitle
- Evidence for Association of Bipolar Disorder to Haplotypes in the 22q12.3 Region Near the Genes Stargazin, IFT27 and Parvalbumin
- Creators
- Stephanie Nissen - Institute for Genomic Medicine, University of California San Diego, La Jolla, CaliforniaSherri Liang - Institute for Genomic Medicine, University of California San Diego, La Jolla, CaliforniaTatyana Shehktman - Institute for Genomic Medicine, University of California San Diego, La Jolla, CaliforniaJohn R Kelsoe - Institute for Genomic Medicine, University of California San Diego, La Jolla, CaliforniaBipolar Genome Study (BiGS)
- Contributors
- James B Potash (Contributor) - University of Iowa, Psychiatry
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.159B(8), pp.941-950
- DOI
- 10.1002/ajmg.b.32099
- PMID
- 23038240
- PMCID
- PMC3665332
- ISSN
- 1552-4841
- eISSN
- 1552-485X
- Grant note
- R01 MH081804 || MH / National Institute of Mental Health : NIMH R01 MH068503 || MH / National Institute of Mental Health : NIMH R01 MH059553 || MH / National Institute of Mental Health : NIMH R01 MH059545 || MH / National Institute of Mental Health : NIMH R01 MH059533 || MH / National Institute of Mental Health : NIMH R01 MH059567 || MH / National Institute of Mental Health : NIMH R01 MH078151 || MH / National Institute of Mental Health : NIMH R01 MH059535 || MH / National Institute of Mental Health : NIMH Z01 MH002810-05 || MH / National Institute of Mental Health : NIMH R01 MH059548 || MH / National Institute of Mental Health : NIMH
- Language
- English
- Date published
- 12/2012
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003985202771
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