Journal article
Evidence for Similar Prefrontal Structural and Functional Alterations in Male and Female Rats Following Chronic Stress or Glucocorticoid Exposure
Cerebral cortex (New York, N.Y. 1991), Vol.30(1), pp.353-370
01/10/2020
DOI: 10.1093/cercor/bhz092
PMCID: PMC7029687
PMID: 31184364
Abstract
Abstract
Previous work of ours and others has documented regressive changes in neuronal architecture and function in the medial prefrontal cortex (mPFC) of male rats following chronic stress. As recent focus has shifted toward understanding whether chronic stress effects on mPFC are sexually dimorphic, here we undertake a comprehensive analysis to address this issue. First, we show that chronic variable stress (14-day daily exposure to different challenges) resulted in a comparable degree of adrenocortical hyperactivity, working memory impairment, and dendritic spine loss in mPFC pyramidal neurons in both sexes. Next, exposure of female rats to 21-day regimen of corticosterone resulted in a similar pattern of mPFC dendritic spine attrition and increase in spine volume. Finally, we examined the effects of another widely used regimen, chronic restraint stress (CRS, 21-day of daily 6-h restraint), on dendritic spine changes in mPFC in both sexes. CRS resulted in response decrements in adrenocortical output (habituation), and induced a pattern of consistent, but less widespread, dendritic spine loss similar to the foregoing challenges. Our data suggest that chronic stress or glucocorticoid exposure induces a relatively undifferentiated pattern of structural and functional alterations in mPFC in both males and females.
Details
- Title: Subtitle
- Evidence for Similar Prefrontal Structural and Functional Alterations in Male and Female Rats Following Chronic Stress or Glucocorticoid Exposure
- Creators
- Rachel M Anderson - Department of Psychological and Brain Sciences, Program in Neuroscience, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USAShane B Johnson - Department of Psychological and Brain Sciences, Program in Neuroscience, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USARyan T Lingg - Department of Psychological and Brain Sciences, Program in Neuroscience, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USADalton C Hinz - Department of Psychological and Brain Sciences, Program in Neuroscience, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USASara A Romig-Martin - Department of Psychological and Brain Sciences, Program in Neuroscience, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USAJason J Radley - Department of Psychological and Brain Sciences, Program in Neuroscience, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Cerebral cortex (New York, N.Y. 1991), Vol.30(1), pp.353-370
- DOI
- 10.1093/cercor/bhz092
- PMID
- 31184364
- PMCID
- PMC7029687
- NLM abbreviation
- Cereb Cortex
- ISSN
- 1047-3211
- eISSN
- 1460-2199
- Publisher
- Oxford University Press
- Grant note
- R56 MH-095972; R01 MH-095972 / National Institutes of Health (10.13039/100000002) National Alliance for Research on Schizophrenia and Depression (10.13039/100009670)
- Language
- English
- Date published
- 01/10/2020
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984070511302771
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