Evidence for Vertical Transmission of HPV from Mothers to Infants

Elaine M Smith; Michael A Parker; Linda M Rubenstein; Thomas H Haugen; Eva Hamsikova; Lubomir P Turek

doi:10.1155/2010/326369

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Evidence for Vertical Transmission of HPV from Mothers to Infants

Journal article

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Peer reviewed

Evidence for Vertical Transmission of HPV from Mothers to Infants

Elaine M Smith, Michael A Parker, Linda M Rubenstein, Thomas H Haugen, Eva Hamsikova and Lubomir P Turek

Infectious diseases in obstetrics and gynecology, Vol.2010, pp.1-7

2010

DOI: 10.1155/2010/326369

PMCID: PMC2838362

PMID: 20300545

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Abstract

Few large studies have evaluated concordance based on a broad spectrum of human papillomavirus (HPV) types in oral and genital specimens of mothers and their recently born infants. This information is important in determining whether HPV vaccines administered prior to pregnancy may be useful for preventing vertical transmission. HPV DNA was positive in 30% of mothers and 1.5% of newborns. Maternal/newborn concordance (HPV+/+ or HPV−/−) was 71%. Among HPV DNA+ mothers, only 3% of their infants were DNA+ and only 1 pair had the same HPV type. Among HPV−women, 0.8% of infants were HPV+. HPV DNA detected in hospitalized newborns reflects current infection transmitted to infants during pregnancy or delivery. None of the mother/baby HPV DNA+ concordance pairs detected viral types found in HPV vaccines suggesting that vaccination prior to pregnancy is unlikely to be efficacious in preventing vertical transmission.

Details

Title: Subtitle: Evidence for Vertical Transmission of HPV from Mothers to Infants
Creators: Elaine M Smith - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA, Department of Obstetrics/Gynecology, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Michael A Parker - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
Linda M Rubenstein - Department of Obstetrics/Gynecology, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Thomas H Haugen - Veterans Affairs Medical Center, Iowa City, IA 52240, USA
Eva Hamsikova - Department of Experimental Virology, Institute of Hematology and Blood Transfusion, U nemocnice 1, 128 20 Prague 2, Czech Republic
Lubomir P Turek - Veterans Affairs Medical Center, Iowa City, IA 52240, USA
Resource Type: Journal article
Publication Details: Infectious diseases in obstetrics and gynecology, Vol.2010, pp.1-7
DOI: 10.1155/2010/326369
PMID: 20300545
PMCID: PMC2838362
NLM abbreviation: Infect Dis Obstet Gynecol
ISSN: 1064-7449
eISSN: 1098-0997
Grant note: DOI: 10.13039/100000072, name: National Institute of Dental and Craniofacial Research, award: R01 DE11979, R01 DE13110
Language: English
Date published: 2010
Academic Unit: Epidemiology; Pathology; Internal Medicine
Record Identifier: 9984047732002771

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