Evidence for a role of developmental genes in the origin of obesity and body fat distribution

Stephane Gesta; Matthias Blüher; Yuji Yamamoto; Andrew W. Norris; Janin Berndt; Susan Kralisch; Jeremie Boucher; Choy Lewis; C. Ronald Kahn

doi:10.1073/pnas.0601752103

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Evidence for a role of developmental genes in the origin of obesity and body fat distribution

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Evidence for a role of developmental genes in the origin of obesity and body fat distribution

Stephane Gesta, Matthias Blüher, Yuji Yamamoto, Andrew W. Norris, Janin Berndt, Susan Kralisch, Jeremie Boucher, Choy Lewis and C. Ronald Kahn

Proceedings of the National Academy of Sciences - PNAS, Vol.103(17), pp.6676-6681

04/14/2006

DOI: 10.1073/pnas.0601752103

PMCID: PMC1458940

PMID: 16617105

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Abstract

Obesity, especially central obesity, is a hereditable trait associated with a high risk for development of diabetes and metabolic disorders. Combined gene expression analysis of adipocyte- and preadipocyte-containing fractions from intraabdominal and subcutaneous adipose tissue of mice revealed coordinated depot-specific differences in expression of multiple genes involved in embryonic development and pattern specification. These differences were intrinsic and persisted during in vitro culture and differentiation. Similar depot-specific differences in expression of developmental genes were observed in human subcutaneous versus visceral adipose tissue. Furthermore, in humans, several genes exhibited changes in expression that correlated closely with body mass index and/or waist/hip ratio. Together, these data suggest that genetically programmed developmental differences in adipocytes and their precursors in different regions of the body play an important role in obesity, body fat distribution, and potential functional differences between internal and subcutaneous adipose tissue.

adipose tissue

Biological Sciences

gene expression

intraabdominal

subcutaneous

Details

Title: Subtitle: Evidence for a role of developmental genes in the origin of obesity and body fat distribution
Creators: Stephane Gesta - Joslin Diabetes Center
Matthias Blüher - Leipzig University
Yuji Yamamoto - Harvard University
Andrew W. Norris - Harvard University
Janin Berndt - Leipzig University
Susan Kralisch - Leipzig University
Jeremie Boucher - Harvard University
Choy Lewis - Harvard University
C. Ronald Kahn - Harvard University
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.103(17), pp.6676-6681
DOI: 10.1073/pnas.0601752103
PMID: 16617105
PMCID: PMC1458940
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 04/14/2006
Academic Unit: Endocrinology and Diabetes; Stead Family Department of Pediatrics; Biochemistry and Molecular Biology
Record Identifier: 9984293073902771

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