Evidence for accelerated vascular aging in bipolar disorder

Simrit K Sodhi; Jonathan Linder; Catherine A Chenard; Del D Miller; William G Haynes; Jess G Fiedorowicz

doi:10.1016/j.jpsychores.2012.06.004

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Evidence for accelerated vascular aging in bipolar disorder

Journal article

Open access

Peer reviewed

Evidence for accelerated vascular aging in bipolar disorder

Simrit K Sodhi, Jonathan Linder, Catherine A Chenard, Del D Miller, William G Haynes and Jess G Fiedorowicz

Journal of psychosomatic research, Vol.73(3), pp.175-179

09/2012

DOI: 10.1016/j.jpsychores.2012.06.004

PMCID: PMC3410319

PMID: 22850256

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https://www.ncbi.nlm.nih.gov/pmc/articles/3410319View

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Abstract

Persons with bipolar disorder face excess risk of cardiovascular disease, although the biobehavioral mechanisms and time course are unclear. We measured vascular stiffness in a cross-sectional sample of participants with bipolar disorder and compared results to published normative data to assess time-course and relationship to behavioral risk factors. 62 individuals with bipolar disorder (33±6.7years; 64% female) underwent non-invasive assessment of arterial stiffness through arterial applanation tonometry. Lifetime tobacco exposure was estimated on clinical interview. Physical activity was assessed using the long-version of the International Physical Activity Questionnaire (IPAQ). A food frequency questionnaire was used to compute Alternate Healthy Eating Index (AHEI), a measure of overall dietary quality. Medication histories were systematically abstracted from pharmacy records. Participants over the age of 32 (median split) had greater arterial stiffness than expected from age-based population norms for pulse wave velocity (PWV) (7.6 vs. 7.0m/s, p=.02) and estimated aortic augmentation pressure (AIx) (14.2 vs. 8.2%, p=.0002). The younger portion of the sample did not differ from population norms on these measures (PWV 6.3 vs. 6.4m/s, p=.45 and AIx 7.6 vs. 7.4%, p=.60). In the older half of the sample, physical activity was inversely associated with AIx and poorer diet marginally associated with PWV. These findings were independent of body mass index (BMI), which was strongly related to arterial stiffness. Risk for vascular disease may be acquired over the long-term course of affective illness. This risk appears to reflect maladaptive health behaviors, which may be amenable to intervention.

Bipolar disorder

Cardiovascular disease

Pulse wave analysis

Physical activity

Diet

Arterial stiffness

Details

Title: Subtitle: Evidence for accelerated vascular aging in bipolar disorder
Creators: Simrit K Sodhi - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, United States
Jonathan Linder - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, United States
Catherine A Chenard - Institute for Clinical and Translational Science, United States
Del D Miller - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, United States
William G Haynes - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, United States
Jess G Fiedorowicz - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, United States
Resource Type: Journal article
Publication Details: Journal of psychosomatic research, Vol.73(3), pp.175-179
DOI: 10.1016/j.jpsychores.2012.06.004
PMID: 22850256
PMCID: PMC3410319
NLM abbreviation: J Psychosom Res
ISSN: 0022-3999
eISSN: 1879-1360
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: 1K23MH083695-01A210, P01 HL014388; DOI: 10.13039/100012138, name: Nellie Ball Research Trust; name: Institute for Clinical and Translational Science at the University of Iowa, award: 5UL1RR024979-05
Language: English
Date published: 09/2012
Academic Unit: Psychiatry; Epidemiology; Iowa Neuroscience Institute; Pharmacy Practice and Science
Record Identifier: 9984065395102771

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