Evidence for causal top-down frontal contributions to predictive processes in speech perception

Thomas E Cope; E Sohoglu; W Sedley; K Patterson; P S Jones; J Wiggins; C Dawson; M Grube; R P Carlyon; T D Griffiths; Matthew H Davis; James B Rowe

doi:10.1038/s41467-017-01958-7

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Evidence for causal top-down frontal contributions to predictive processes in speech perception

Journal article

Open access

Peer reviewed

Evidence for causal top-down frontal contributions to predictive processes in speech perception

Thomas E Cope, E Sohoglu, W Sedley, K Patterson, P S Jones, J Wiggins, C Dawson, M Grube, R P Carlyon, T D Griffiths, …

Nature communications, Vol.8(1), pp.2154-16

12/18/2017

DOI: 10.1038/s41467-017-01958-7

PMCID: PMC5735133

PMID: 29255275

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Abstract

Perception relies on the integration of sensory information and prior expectations. Here we show that selective neurodegeneration of human frontal speech regions results in delayed reconciliation of predictions in temporal cortex. These temporal regions were not atrophic, displayed normal evoked magnetic and electrical power, and preserved neural sensitivity to manipulations of sensory detail. Frontal neurodegeneration does not prevent the perceptual effects of contextual information; instead, prior expectations are applied inflexibly. The precision of predictions correlates with beta power, in line with theoretical models of the neural instantiation of predictive coding. Fronto-temporal interactions are enhanced while participants reconcile prior predictions with degraded sensory signals. Excessively precise predictions can explain several challenging phenomena in frontal aphasias, including agrammatism and subjective difficulties with speech perception. This work demonstrates that higher-level frontal mechanisms for cognitive and behavioural flexibility make a causal functional contribution to the hierarchical generative models underlying speech perception.

Acoustic Stimulation

Aged

Brain Mapping

Electroencephalography

Female

Frontal Lobe - physiopathology

Humans

Magnetoencephalography

Male

Nerve Net - physiopathology

Primary Progressive Nonfluent Aphasia - physiopathology

Speech - physiology

Speech Perception - physiology

Temporal Lobe - physiopathology

Details

Title: Subtitle: Evidence for causal top-down frontal contributions to predictive processes in speech perception
Creators: Thomas E Cope - University of Cambridge
E Sohoglu - Medical Research Council
W Sedley - Newcastle University
K Patterson - University of Cambridge
P S Jones - University of Cambridge
J Wiggins - University of Cambridge
C Dawson - University of Cambridge
M Grube - Newcastle University
R P Carlyon - MRC Cognition and Brain Sciences Unit
T D Griffiths - Newcastle University
Matthew H Davis - MRC Cognition and Brain Sciences Unit
James B Rowe - MRC Cognition and Brain Sciences Unit
Resource Type: Journal article
Publication Details: Nature communications, Vol.8(1), pp.2154-16
DOI: 10.1038/s41467-017-01958-7
PMID: 29255275
PMCID: PMC5735133
ISSN: 2041-1723
eISSN: 2041-1723
Grant note: MC_UU_00005/5 / Medical Research Council Wellcome Trust MC_U105559842 / Medical Research Council P50 DC000242 / NIDCD NIH HHS MC_U105597119 / Medical Research Council MC_UU_00005/12 / Medical Research Council MC_U105580446 / Medical Research Council MC_UU_00005/3 / Medical Research Council
Language: English
Date published: 12/18/2017
Academic Unit: Psychological and Brain Sciences
Record Identifier: 9984627287602771

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