Journal article
Evidence for clonal selection of gamma/delta T cells in response to a human pathogen
The Journal of experimental medicine, Vol.174(3), pp.683-692
09/01/1991
DOI: 10.1084/jem.174.3.683
PMCID: PMC2118935
PMID: 1651977
Abstract
T cells bearing gamma/delta antigen receptors comprise a resident population of intraepithelial lymphocytes in organs such as skin, gut, and lungs, where they are strategically located to contribute to the initial defense against infection. An important unsolved question about antigen-driven gamma/delta T cell responses regards the breadth of their T cell receptor (TCR) repertoire, since many specific epithelial compartments in mice display limited diversity. We have examined the diversity of TCR delta gene expression among human gamma/delta T cells from skin lesions induced by intradermal challenge with Mycobacterium leprae. We show that the vast majority of gamma/delta cells from M. leprae lesions use either V delta 1-J delta 1 or V delta 2-J delta 1 gene rearrangements and, within a given region of the lesion, display limited junctional diversity. This contrasts markedly with the extensive diversity of gamma/delta T cells from peripheral blood of these same individuals, as well as skin from normal donors. These results indicate that the gamma/delta response to M. leprae involves the selection of a limited number of clones from among a diverse repertoire, probably in response to specific mycobacterial and/or host antigens.
Details
- Title: Subtitle
- Evidence for clonal selection of gamma/delta T cells in response to a human pathogen
- Creators
- Koichi Uyemura - Division of Dermatology, UCLA School of Medicine 90024Robert J Deans - Division of Dermatology, UCLA School of Medicine 90024Hamid Band - Division of Dermatology, UCLA School of Medicine 90024Jeffrey Ohmen - Division of Dermatology, UCLA School of Medicine 90024Govindaswamy Panchamoorthy - Division of Dermatology, UCLA School of Medicine 90024Craig T Morita - Division of Dermatology, UCLA School of Medicine 90024Thomas H Rea - Division of Dermatology, UCLA School of Medicine 90024Robert L Modlin - Division of Dermatology, UCLA School of Medicine 90024
- Resource Type
- Journal article
- Publication Details
- The Journal of experimental medicine, Vol.174(3), pp.683-692
- DOI
- 10.1084/jem.174.3.683
- PMID
- 1651977
- PMCID
- PMC2118935
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- Language
- English
- Date published
- 09/01/1991
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094768602771
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