Journal article
Evidence for the induction of cytochrome P-452 in rat liver by Aroclor 1254, a commercial mixture of polychlorinated biphenyls
FEBS letters, Vol.247(2), pp.327-329
1989
DOI: 10.1016/0014-5793(89)81362-6
PMID: 2497034
Abstract
We have examined the ability of a commercial mixture of polychlorinated biphenyls (Aroclor 1254) to induce hepatic cytochrome P-452-linked enzyme activities in rat and pigeon liver five days after its intraperitoneal injection. The results provide evidence that, at the doses used, Aroclor 1254 induces cytochrome P-452-linked enzyme activities in rats, but not in pigeons. This inductive effect was previously regarded as being specific for hypolipidemic drugs and phthalate ester plasticisers.
Details
- Title: Subtitle
- Evidence for the induction of cytochrome P-452 in rat liver by Aroclor 1254, a commercial mixture of polychlorinated biphenyls
- Creators
- J.T BorlakogluJ.D Edwards-Webb - Department of Human Nutrition, AFRC Institute of Food Research, Reading Laboratory, Shinfield, Berkshire RG2 9AT, EnglandR.R DilsJ.P.G Wilkins - MAFF Harpenden Laboratory, Hatching Green, Harpenden, Herts AL5 2BD, EnglandL.W Robertson - Graduate Center for Toxicology, 204 Funkhouser Building, University of Kentucky, Lexington, KY 40506-0054, USA
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.247(2), pp.327-329
- DOI
- 10.1016/0014-5793(89)81362-6
- PMID
- 2497034
- NLM abbreviation
- FEBS Lett
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 1989
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002314902771
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