Journal article
Evidence for the involvement of bacterial superantigens in psoriasis, atopic dermatitis, and Kawasaki syndrome
FEMS Microbiology Letters, Vol.192(1), pp.1-7
2000
DOI: 10.1016/S0378-1097(00)00400-6
PMID: 11040420
Abstract
A growing body of evidence implicates streptococcal and staphylococcal superantigens in the development of psoriasis, atopic dermatitis and Kawasaki syndrome. In each of these illnesses, an abnormal state of immunologic activity is observed. Superantigens, which have a unique ability to activate large numbers of lymphocytes, are likely to contribute to these disorders in a number of ways. The demonstrated activities of bacterial superantigens include increasing the number of circulating lymphocytes, with activation of autoreactive subsets, upregulation of tissue homing receptors on circulating lymphocytes, and local activation of immune cells within affected tissues. Through these and other mechanisms, superantigens have a proven ability to induce high levels of inflammatory cytokines and/or initiate autoimmune responses that contribute to the development of skin and vascular disorders. Though development of the illnesses discussed in this review are highly complex processes, superantigens may well play a critical role in their onset or maintenance. Understanding superantigen function may elucidate potential therapeutic strategies for these disorders.
Details
- Title: Subtitle
- Evidence for the involvement of bacterial superantigens in psoriasis, atopic dermatitis, and Kawasaki syndrome
- Creators
- Jeremy M Yarwood - Department of Microbiology, University of Minnesota Medical School, Box 196 FUMC, 420 Delaware St. SE, Minneapolis, MN 55455, USADonald Y.M Leung - Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USAPatrick M Schlievert - Department of Microbiology, University of Minnesota Medical School, Box 196 FUMC, 420 Delaware St. SE, Minneapolis, MN 55455, USA
- Resource Type
- Journal article
- Publication Details
- FEMS Microbiology Letters, Vol.192(1), pp.1-7
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0378-1097(00)00400-6
- PMID
- 11040420
- ISSN
- 0378-1097
- eISSN
- 1574-6968
- Language
- English
- Date published
- 2000
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001158702771
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