Journal article
Evidence for the involvement of endotoxin in toxic shock syndrome
The Journal of infectious diseases, Vol.155(4), pp.682-689
04/1987
DOI: 10.1093/infdis/155.4.682
PMID: 2950183
Abstract
The toxicity of toxic shock syndrome (TSS) toxin-1 (TSST-1) was evaluated in female, specific pathogen-free rabbits and conventional rabbits. Results after intravenous injections of TSST-1 given to both types of rabbits indicated that specific pathogen-free rabbits were resistant to the lethal effects observed in conventional rabbits. Lethality could be prevented by simultaneous administration of polymyxin B, and analysis of serum before and after dosing confirmed that dosing with TSST-1 resulted in circulating endotoxin. Analysis of sera from humans with TSS showed that endotoxin was present in acute-phase sera but not in convalescent-phase sera. These observations suggest that endogenous endotoxin contributes to rabbit susceptibility to TSST-1 and may play a role in human TSS.
Details
- Title: Subtitle
- Evidence for the involvement of endotoxin in toxic shock syndrome
- Creators
- Roger L StonePatrick M Schlievert
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.155(4), pp.682-689
- DOI
- 10.1093/infdis/155.4.682
- PMID
- 2950183
- NLM abbreviation
- J Infect Dis
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Publisher
- United States
- Language
- English
- Date published
- 04/1987
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984002381402771
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