Journal article
Evidence of Gene-Environment Interaction for the RUNX2 Gene and Environmental Tobacco Smoke in Controlling the Risk of Cleft Lip with/without Cleft Palate
Birth defects research. A Clinical and molecular teratology, Vol.94(2), pp.76-83
02/2012
DOI: 10.1002/bdra.22885
PMCID: PMC3608124
PMID: 22241686
Abstract
This study examined the association between 49 markers in the Runt-related transcription factor 2 (
RUNX2
) gene and nonsyndromic cleft lip with/without cleft palate (CL/P) among 326 Chinese case-parent trios, while considering gene-environment (GxE) interaction and parent-of-origin effects. Five single-nucleotide polymorphisms (SNPs) showed significant evidence of linkage and association with CL/P and these results were replicated in an independent European sample of 825 case-parent trios. We also report compelling evidence for interaction between markers in
RUNX2
and environmental tobacco smoke (ETS). Although most marginal SNP effects (i.e., ignoring maternal exposures) were not statistically significant, eight SNPs were significant when considering possible interaction with ETS when testing for gene (G) and GxE interaction simultaneously or when considering GxE alone. Independent samples from European populations showed consistent evidence of significant GxETS interaction at two SNPs (
rs6904353
and
rs7748231
). Our results suggest genetic variation in
RUNX2
may influence susceptibility to CL/P through interacting with ETS.
Details
- Title: Subtitle
- Evidence of Gene-Environment Interaction for the RUNX2 Gene and Environmental Tobacco Smoke in Controlling the Risk of Cleft Lip with/without Cleft Palate
- Creators
- Tao Wu - Peking University School of Public Health, Beijing, ChinaM. Daniele Fallin - Johns Hopkins Bloomberg School of Public Health, Baltimore, MarylandMin Shi - Biostatistics Branch, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, Durham, North CarolinaIngo Ruczinski - Johns Hopkins Bloomberg School of Public Health, Baltimore, MarylandKung-Yee Liang - Johns Hopkins Bloomberg School of Public Health, Baltimore, MarylandJacqueline B Hetmanski - Johns Hopkins Bloomberg School of Public Health, Baltimore, MarylandHong Wang - Peking University School of Public Health, Beijing, ChinaRoxann G Ingersoll - Johns Hopkins Bloomberg School of Public Health, Baltimore, MarylandShangzhi Huang - Peking Union Medical College, Beijing, ChinaXiaoqian Ye - Mount Sinai School of Medicine, New York, New YorkYah-Huei Wu-Chou - Chang Gung Memorial Hospital, Taoyuan, TaiwanPhilip K Chen - Chang Gung Memorial Hospital, Taoyuan, TaiwanEthylin Wang Jabs - Johns Hopkins School of Medicine, Baltimore, MarylandBing Shi - West China College of Stomatology, Sichuan University, Sichuan, ChinaRichard Redett - Johns Hopkins School of Medicine, Baltimore, MarylandAlan F Scott - Johns Hopkins School of Medicine, Baltimore, MarylandJeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, IowaMary L Marazita - University of Pittsburgh, School of Dental Medicine, Pittsburgh, PennsylvaniaRonald G Munger - Utah State University, Logan, UtahTerri H Beaty - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
- Resource Type
- Journal article
- Publication Details
- Birth defects research. A Clinical and molecular teratology, Vol.94(2), pp.76-83
- DOI
- 10.1002/bdra.22885
- PMID
- 22241686
- PMCID
- PMC3608124
- NLM abbreviation
- Birth Defects Res A Clin Mol Teratol
- ISSN
- 1542-0752
- eISSN
- 1542-0760
- Publisher
- Wiley
- Grant note
- R21 DE013707 || DE / National Institute of Dental and Craniofacial Research : NIDCR U01 DE020073 || DE / National Institute of Dental and Craniofacial Research : NIDCR U01 DE018993 || DE / National Institute of Dental and Craniofacial Research : NIDCR R01 DE014581 || DE / National Institute of Dental and Craniofacial Research : NIDCR
- Language
- English
- Date published
- 02/2012
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Orthopedics and Rehabilitation; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research; Internal Medicine
- Record Identifier
- 9984025355902771
Metrics
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