Journal article
Evidence of a greater functional sympatholysis in habitually aerobic trained postmenopausal women
Journal of applied physiology (1985), Vol.124(3), pp.583-591
03/01/2018
DOI: 10.1152/japplphysiol.00411.2017
PMCID: PMC5899268
PMID: 28970201
Abstract
Habitual aerobic exercise attenuates elevated vasoconstriction during acute exercise (functional sympatholysis) in older men; however, this effect remains unknown in postmenopausal women (PMW). This study tested the hypothesis that PMW who participate in habitual aerobic exercise demonstrate a greater functional sympatholysis compared with their untrained counterparts. Nineteen PMW (untrained
n
= 9 vs. trained
n
= 10) performed 5 min of steady-state (SS) forearm exercise at relative [10% and 20% of maximum voluntary contraction (MVC)] and absolute (5 kg) contraction intensities. Lower-body negative pressure (LBNP) was used to increase sympathetic vasoconstriction during rest and forearm exercise. Brachial artery diameter and blood velocities (via Doppler ultrasound) determined forearm blood flow (FBF; ml/min). Forearm muscle oxygen consumption (
V
˙
O
2
m
; ml/min) and arteriovenous oxygen difference (a-vO
2diff
) were estimated during SS-exercise and SS-exercise with LBNP. Forearm vascular conductance (FVC; ml·min
−1
·100 mmHg
−1
) was calculated from FBF and mean arterial pressure (MAP; mmHg). Vasoconstrictor responsiveness was determined as the %change in FVC during LBNP. The reduction in FVC (% change FVC) during LBNP was lower in trained compared with untrained PMW at 10% MVC (−7.3 ± 1.2% vs. −13.0 ± 1.1%;
P
< 0.05), 20% MVC (−4.4 ± 0.8% vs. −8.6 ± 1.4%;
P
< 0.05), and 5 kg (−5.3 ± 0.8% vs. −8.9 ± 1.4%;
P
< 0.05) conditions, whereas there were no differences at rest (−32.7 ± 4.4% vs. −33.7 ± 4.0%). Peripheral (FVC, FBF, and
V
˙
O
2
m
) and the magnitude change in systemic hemodynamics (heart rate and MAP) did not differ between groups during exercise. Collectively, the findings present the first evidence suggesting that PMW who participate in aerobic exercise demonstrate a greater functional sympatholysis compared with untrained PMW during mild to moderate forearm exercise.
NEW & NOTEWORTHY
Habitual aerobic exercise attenuates the elevated sympathetic nervous system-induced vasoconstriction during an acute bout of exercise (improved functional sympatholysis) in aging men; however, this effect remains unknown in postmenopausal women (PMW). The novel findings of this study suggest that habitual aerobic exercise results in an enhanced functional sympatholysis in PMW. Conversely, habitual aerobic exercise does not alter blood flow and oxygen utilization during acute forearm exercise compared with PMW who do not habitually exercise.
Details
- Title: Subtitle
- Evidence of a greater functional sympatholysis in habitually aerobic trained postmenopausal women
- Creators
- Nicholas T Kruse - Department of Physical Therapy and Rehabilitation Science, Carver College of MedicineWilliam E Hughes - Department of Physical Therapy and Rehabilitation Science, Carver College of MedicineSatoshi Hanada - Department of Anesthesia, Carver College of MedicineKenichi Ueda - Department of Anesthesia, Carver College of MedicineJoshua M Bock - Department of Physical Therapy and Rehabilitation Science, Carver College of MedicineErika Iwamoto - Department of Physical Therapy and Rehabilitation Science, Carver College of MedicineDarren P Casey - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.124(3), pp.583-591
- Publisher
- American Physiological Society; Bethesda, MD
- DOI
- 10.1152/japplphysiol.00411.2017
- PMID
- 28970201
- PMCID
- PMC5899268
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Grant note
- HL-105467; T32HL-007121 / ; ;
- Alternative title
- EXERCISE, POSTMENOPAUSAL WOMEN, AND VASOCONSTRICTOR TONE
- Language
- English
- Date published
- 03/01/2018
- Academic Unit
- Anesthesia; Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984007167302771
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