Journal article
Evidence of random structural features in the heparin polymer
Biochemistry (Easton), Vol.24(26), pp.7805-7810
1985
DOI: 10.1021/bi00347a045
PMID: 4092040
Abstract
The first use of computer-simulation studies to examine heparin's structure has been reported. The product distributions obtained when porcine mucosal heparins were depolymerized with heparinase have been compared to computer-simulated distributions. The modeled distribution was relatively unaffected by the polydispersity and molecular weight of heparin. However, the percent of heparinase-cleavable glycosidic linkages and their distribution throughout the polymer resulted in a marked change in the simulated product distribution. The similarity between experimentally observed and computer-simulated product distributions is consistent with the random distribution of heparinase-cleavable sites in porcine mucosal heparin. Finally, a random distribution of N-acetyl residues with respect to heparinase-cleavable sites was experimentally observed.
Details
- Title: Subtitle
- Evidence of random structural features in the heparin polymer
- Creators
- Robert J Linhardt - Univ. Iowa, coll. pharmacy, Iowa City IA 52242, United StatesZohar M Merchant - Univ. Iowa, coll. pharmacy, Iowa City IA 52242, United StatesKevin G Rice - Univ. Iowa, coll. pharmacy, Iowa City IA 52242, United StatesYeong S Kim - Univ. Iowa, coll. pharmacy, Iowa City IA 52242, United StatesGerald L Fitzgerald - Massachusetts Institute of TechnologyArthur C Grant - Univ. Iowa, coll. pharmacy, Iowa City IA 52242, United StatesRobert Langer - Massachusetts Institute of Technology
- Resource Type
- Journal article
- Publication Details
- Biochemistry (Easton), Vol.24(26), pp.7805-7810
- DOI
- 10.1021/bi00347a045
- PMID
- 4092040
- NLM abbreviation
- Biochemistry
- ISSN
- 0006-2960
- eISSN
- 1520-4995
- Publisher
- American Chemical Society; Washington, DC
- Language
- English
- Date published
- 1985
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984065502302771
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