Journal article
Evidence of within-facility patient-patient Clostridiodes difficile infection spread across diverse settings
Epidemiology and infection, Vol.151, e4
12/11/2022
DOI: 10.1017/S0950268822001893
PMCID: PMC9990401
PMID: 36502810
Appears in UI Libraries Support Open Access
Abstract
Previous studies have suggested that a hospital patient's risk of developing healthcare facility-onset (HCFO) Clostridioides difficile infections (CDIs) increases with the number of concurrent spatially proximate patients with CDI, termed CDI pressure. However, these studies were performed either in a single institution or in a single state with a very coarse measure of concurrence. We conducted a retrospective case-control study involving over 17.5 million inpatient visits across 700 hospitals in eight US states. We built a weighted, directed network connecting overlapping inpatient visits to measure facility-level CDI pressure. We then matched HCFO-CDIs with non-CDI controls on facility, comorbidities and demographics and performed a conditional logistic regression to determine the odds of developing HCFO-CDI given the number of coincident patient visits with CDI. On average, cases' visits coincided with 9.2 CDI cases, which for an individual with an average length of stay corresponded to an estimated 17.7% (95% CI 12.9-22.7%) increase in the odds of acquiring HCFO-CDI compared to an inpatient visit without concurrent CDI cases or fully isolated from both direct and indirect risks from concurrent CDI cases. These results suggest that, either directly or indirectly, hospital patients with CDI lead to CDIs in non-infected patients with temporally overlapping visits.
Details
- Title: Subtitle
- Evidence of within-facility patient-patient Clostridiodes difficile infection spread across diverse settings
- Creators
- Samuel Justice - University of IowaDaniel K Sewell - University of IowaHaomin Li - Department of Biostatistics, University of Iowa, USAAaron C Miller - University of IowaPhilip M Polgreen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Epidemiology and infection, Vol.151, e4
- DOI
- 10.1017/S0950268822001893
- PMID
- 36502810
- PMCID
- PMC9990401
- NLM abbreviation
- Epidemiol Infect
- ISSN
- 0950-2688
- eISSN
- 1469-4409
- Publisher
- Cambridge University Press
- Grant note
- 1 U01 CK000594-01-00 / CDC HHS 5 U01 CK000531-02 / CDC HHS
- Language
- English
- Date published
- 12/11/2022
- Academic Unit
- Infectious Diseases; Epidemiology; Biostatistics; Injury Prevention Research Center; Public Policy Center (Archive); Internal Medicine
- Record Identifier
- 9984332737002771
Metrics
10 Record Views