Journal article
Evidence that Disruption of the Blood-Brain Barrier Precedes Reduction in Cerebral Blood Flow in Hypertensive Encephalopathy
Hypertension (Dallas, Tex. 1979), Vol.6(2 Suppl I), pp.I-75-I-81
03/1984
DOI: 10.1161/01.HYP.6.2_Pt_2.I75
PMID: 6724673
Abstract
Alternative hypotheses concerning the pathogenesis of hypertensive encephalopathy are that vasospasm produces cerebral ischemia and cerebral edema, or that passive dilation of cerebral vessels during severe hypertension produces disruption of the blood-brain barrier and cerebral edema. Stroke-prone spontaneously hypertensive rats (SHRSP) were studied when they developed signs of neurological dysfunction. We measured regional cerebral blood flow (rCBF) with C-iodoantipyrine, and permeability of the blood-brain barrier with Evans blue dye. Twelve rats had focal disruption of the barrier without histological evidence of ischemic infarction or cerebral hemorrhageareas with disruption of the barrier had severe focal edema in seven rats and minimal edema in five rats. In areas with disruption of the barrier and marked focal edema, rCBF was decreased to 38 ± 8 (mean ± SE) ml/min/lOOg vs 102 ± 13 (p<0.05) in other areas of the ipsilateral hemisphere, and 86 ± 16 in the homologous area of the contralateral hemisphere (p<0.05). In contrast, in areas with disruption of the blood-brain barrier with only minimal edema, rCBF was normal or increasedrCBF was 100 ± 11 ml/min/100 g vs 85 ± 12 in other areas of the ipsilateral hemisphere (p>0.05) and 64 ± 8 in the homologous area contralaterally (p<0.05). The findings indicate that edema precedes reduction in rCBF in SHRSP and suggest that the initiating event in hypertensive encephalopathy is disruption of the blood-brain barrier, and not vasospasm.
Details
- Title: Subtitle
- Evidence that Disruption of the Blood-Brain Barrier Precedes Reduction in Cerebral Blood Flow in Hypertensive Encephalopathy
- Creators
- KINYA TAMAKI - Veterans Administration Medical Center, Department of Medicine and Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa; and Laboratory of Neurobiology, Cornell Medical Center, New York. New YorkSEIZO SADOSHIMAGARY BAUMBACHCONSTANTINO IADECOLADONALD REISDONALD HEISTAD
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.6(2 Suppl I), pp.I-75-I-81
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.HYP.6.2_Pt_2.I75
- PMID
- 6724673
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 03/1984
- Academic Unit
- Pathology; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040567402771
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