Evidence that acetylsalicylic acid attenuates inflammation in the walls of human cerebral aneurysms: preliminary results

David M Hasan; Nohra Chalouhi; Pascal Jabbour; Aaron S Dumont; David K Kung; Vincent A Magnotta; William L Young; Tomoki Hashimoto; H Richard Winn; Donald Heistad

doi:10.1161/JAHA.112.000019

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Evidence that acetylsalicylic acid attenuates inflammation in the walls of human cerebral aneurysms: preliminary results

Journal article

Open access

Evidence that acetylsalicylic acid attenuates inflammation in the walls of human cerebral aneurysms: preliminary results

David M Hasan, Nohra Chalouhi, Pascal Jabbour, Aaron S Dumont, David K Kung, Vincent A Magnotta, William L Young, Tomoki Hashimoto, H Richard Winn and Donald Heistad

Journal of the American Heart Association, Vol.2(1), pp.e000019-n/a

02/22/2013

DOI: 10.1161/JAHA.112.000019

PMCID: PMC3603234

PMID: 23525414

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Abstract

Inflammatory cells and molecules may play a critical role in formation and rupture of cerebral aneurysms. Recently, an epidemiologic study reported that acetylsalicylic acid (ASA) decreases the risk of aneurysm rupture. The goal of this study was to determine the effects of ASA on inflammatory cells and molecules in the walls of human cerebral aneurysms, using radiographic and histological techniques. Eleven prospectively enrolled patients harboring unruptured intracranial aneurysms were randomized into an ASA-treated (81 mg daily) group (n=6) and an untreated (control) group (n=5). Aneurysms were imaged at baseline using ferumoxytol-enhanced MRI to estimate uptake by macrophages. After 3 months, patients were reimaged before undergoing microsurgical clipping. Aneurysm tissues were collected for immunostaining with monoclonal antibodies for cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), microsomal prostaglandin E2 synthase-1 (mPGES-1), and macrophages. A decrease in signal intensity on ferumoxytol-enhanced MRI was observed after 3 months of ASA treatment. Expression of COX-2 (but not COX-1), mPGES-1, and macrophages was lower in the ASA group than in the control group. This study provides preliminary radiographical and histological evidence that ASA may attenuate the inflammatory process in the walls of human cerebral aneurysms. URL: http://www.clinicaltrials.gov. Unique identifier: NCT01710072.

Immunohistochemistry

Magnetic Resonance Imaging

Prospective Studies

Humans

Middle Aged

Male

Tomography, X-Ray Computed

Intracranial Aneurysm - diagnosis

Cerebral Angiography - methods

Angiography, Digital Subtraction

Cerebral Arteries - drug effects

Time Factors

Inflammation - drug therapy

Inflammation Mediators - metabolism

Female

Aspirin - therapeutic use

Inflammation - diagnosis

Intracranial Aneurysm - drug therapy

Intramolecular Oxidoreductases - metabolism

Macrophages - immunology

Cerebral Arteries - immunology

Treatment Outcome

Inflammation - immunology

Intracranial Aneurysm - surgery

Intracranial Aneurysm - immunology

Iowa

Anti-Inflammatory Agents, Non-Steroidal - therapeutic use

Cerebral Arteries - metabolism

Prostaglandin-E Synthases

Cerebral Arteries - pathology

Cyclooxygenase 2 - metabolism

Macrophages - drug effects

Aged

Cyclooxygenase 1 - metabolism

Inflammation - surgery

Details

Title: Subtitle: Evidence that acetylsalicylic acid attenuates inflammation in the walls of human cerebral aneurysms: preliminary results
Creators: David M Hasan - Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. david-hasan@uiowa.edu
Nohra Chalouhi
Pascal Jabbour
Aaron S Dumont
David K Kung
Vincent A Magnotta
William L Young
Tomoki Hashimoto
H Richard Winn
Donald Heistad
Resource Type: Journal article
Publication Details: Journal of the American Heart Association, Vol.2(1), pp.e000019-n/a
DOI: 10.1161/JAHA.112.000019
PMID: 23525414
PMCID: PMC3603234
NLM abbreviation: J Am Heart Assoc
ISSN: 2047-9980
eISSN: 2047-9980
Publisher: England
Grant note: P01 NS044155 / NINDS NIH HHS R03NS07922 / NINDS NIH HHS R01 NS055876 / NINDS NIH HHS
Language: English
Date published: 02/22/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Cardiovascular Medicine; Neuroscience and Pharmacology; Neurosurgery; Otolaryngology; Internal Medicine
Record Identifier: 9984040275702771

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