Journal article
Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task
International journal of psychophysiology, Vol.62(2), pp.262-271
2006
DOI: 10.1016/j.ijpsycho.2006.05.012
PMID: 16887227
Abstract
This study investigates early evoked gamma band activity in male adolescent subjects at high risk for alcoholism (HR;
n
=
68) and normal controls (LR;
n
=
27) during a visual oddball task. A time–frequency representation method was applied to EEG data in order to obtain stimulus related early evoked (phase-locked) gamma band activity (29–45 Hz) and was analyzed within a 0–150 ms time window range. Significant reduction of the early evoked gamma band response in the frontal and parietal regions during target stimulus processing was observed in HR subjects compared to LR subjects. Additionally, the HR group showed less differentiation between target and non-target stimuli in both frontal and parietal regions compared to the LR group, indicating difficulty in early stimulus processing, probably due to a dysfunctional frontoparietal attentional network. The results indicate that the deficient early evoked gamma band response may precede the development of alcoholism and could be a potential endophenotypic marker of alcoholism risk.
Details
- Title: Subtitle
- Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task
- Creators
- Ajayan Padmanabhapillai - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USAYongqiang Tang - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USAMohini Ranganathan - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USAMadhavi Rangaswamy - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USAKevin A Jones - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USADavid B Chorlian - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USAChella Kamarajan - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USAArthur Stimus - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USASamuel Kuperman - University of Iowa Hospitals, Division of Child Psychiatry, Iowa City, IA 52242, USAJohn Rohrbaugh - Washington University-Division of Family Studies, St. Louis, MO 63108, USASean J O'Connor - Department of Psychiatry, Institute of Psychiatric Research, Indiana University Medical Center, Indianapolis, IN 46202, USALance O Bauer - Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030, USAMarc A Schuckit - Department of Psychiatry,University of California, San Diego and San Diego Veterans Healthcare System, 3350 La Jolla Village Dr., San Diego, CA 92161-2002, USAHenri Begleiter - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USABernice Porjesz - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USA
- Resource Type
- Journal article
- Publication Details
- International journal of psychophysiology, Vol.62(2), pp.262-271
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.ijpsycho.2006.05.012
- PMID
- 16887227
- ISSN
- 0167-8760
- eISSN
- 1872-7697
- Language
- English
- Date published
- 2006
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984004094002771
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