Journal article
Evoked mid-frontal activity predicts cognitive dysfunction in Parkinson’s disease
Journal of neurology, neurosurgery and psychiatry, Vol.94(11), pp.945-953
11/2023
DOI: 10.1136/jnnp-2022-330154
PMCID: PMC10592174
PMID: 37263767
Abstract
BackgroundCognitive dysfunction is a major feature of Parkinson’s disease (PD), but the pathophysiology remains unknown. One potential mechanism is abnormal low-frequency cortical rhythms which engage cognitive functions and are deficient in PD. We tested the hypothesis that mid-frontal delta/theta rhythms predict cognitive dysfunction in PD.MethodWe recruited 100 patients with PD and 49 demographically similar control participants who completed a series of cognitive control tasks, including the Simon, oddball and interval-timing tasks. We focused on cue-evoked delta (1–4 Hz) and theta (4–7 Hz) rhythms from a single mid-frontal EEG electrode (cranial vertex (Cz)) in patients with PD who were either cognitively normal, with mild-cognitive impairments (Parkinson’s disease with mild-cognitive impairment) or had dementia (Parkinson’s disease dementia).ResultsWe found that PD-related cognitive dysfunction was associated with increased response latencies and decreased mid-frontal delta power across all tasks. Within patients with PD, the first principal component of evoked electroencephalography features from a single electrode (Cz) strongly correlated with clinical metrics such as the Montreal Cognitive Assessment score (r=0.34) and with National Institutes of Health Toolbox Executive Function score (r=0.46).ConclusionsThese data demonstrate that cue-evoked mid-frontal delta/theta rhythms directly relate to cognition in PD. Our results provide insight into the nature of low-frequency frontal rhythms and suggest that PD-related cognitive dysfunction results from decreased delta/theta activity. These findings could facilitate the development of new biomarkers and targeted therapies for cognitive symptoms of PD.
Details
- Title: Subtitle
- Evoked mid-frontal activity predicts cognitive dysfunction in Parkinson’s disease
- Creators
- Arun Singh - University of South DakotaRachel C Cole - University of IowaArturo I Espinoza - University of IowaJan R Wessel - University of IowaJames F Cavanagh - University of New MexicoNandakumar S Narayanan - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of neurology, neurosurgery and psychiatry, Vol.94(11), pp.945-953
- DOI
- 10.1136/jnnp-2022-330154
- PMID
- 37263767
- PMCID
- PMC10592174
- NLM abbreviation
- J Neurol Neurosurg Psychiatry
- ISSN
- 0022-3050
- eISSN
- 1468-330X
- Publisher
- BMJ Publishing Group Ltd
- Grant note
- F32 AG069445-01 / NRSA P20NS123151; R01NS100849 / NIH
- Language
- English
- Electronic publication date
- 06/01/2023
- Date published
- 11/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984420933802771
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